Implantable Electrical Stimulation at Dorsal Root Ganglions Accelerates Osteoporotic Fracture Healing via Calcitonin Gene-Related Peptide.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced science"
DOI: 10.1002/advs.202103005
Abstract: The neuronal engagement of the peripheral nerve system plays a crucial role in regulating fracture healing, but how to modulate the neuronal activity to enhance fracture healing remains unexploited. Here it is shown that electrical… read more here.
Keywords: fracture; electrical stimulation; gene related; fracture healing ... See more keywords
Bone fracture healing under Ilizarov fixator: Influence of fixator configuration, fracture geometry, and loading.
Sign Up to like & getrecommendations! Published in 2019 at "International journal for numerical methods in biomedical engineering"
DOI: 10.1002/cnm.3199
Abstract: This study aims to enhance the understanding of the relationship between Ilizarov fixator configuration and its effects on bone fracture healing. Using Taylor spatial frame (TSF) as an example, the roles of critical parameters (ie,… read more here.
Keywords: influence; configuration; fracture; geometry ... See more keywords
The optimal design of 3D‐printed lattice bone plate by considering fracture healing mechanism
Sign Up to like & getrecommendations! Published in 2023 at "International Journal for Numerical Methods in Biomedical Engineering"
DOI: 10.1002/cnm.3682
Abstract: The biomechanical stimulus is the most important factor for fracture healing and mainly determined by the structural stiffness of bone plate. Currently, the materials commonly used in bone plates are stainless steel and titanium, which… read more here.
Keywords: bone plate; bone; design; fracture healing ... See more keywords
Enhancement of Impaired MRSA‐Infected Fracture Healing by Combinatorial Antibiotics and Modulation of Sustained Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4570
Abstract: Fracture healing is impaired in the setting of infection, which begets protracted inflammation. The most problematic causative agent of musculoskeletal infection is methicillin‐resistant Staphylococcus aureus (MRSA). We hypothesized that modulation of excessive inflammation combined with… read more here.
Keywords: inflammation; fracture; mrsa infected; fracture healing ... See more keywords
Wnt1 Boosts Fracture Healing by Enhancing Bone Formation in the Fracture Callus
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4797
Abstract: Despite considerable improvement in fracture care, 5%–10% of all fractures still heal poorly or result in nonunion formation. Therefore, there is an urgent need to identify new molecules that can be used to improve bone… read more here.
Keywords: fracture callus; fracture; bone; wnt1 ... See more keywords
Osteogenic Differentiation of Periosteal Cells During Fracture Healing
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25641
Abstract: Five to ten percent of fractures fail to heal normally leading to additional surgery, morbidity, and altered quality of life. Fracture healing involves the coordinated action of stem cells primarily coming from the periosteum which… read more here.
Keywords: periosteal cells; differentiation periosteal; differentiation; fracture healing ... See more keywords
Osteocytic connexin 43 channels affect fracture healing
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28581
Abstract: The cross‐talk between cells is very critical for moving forward fracture healing in an orderly manner. Connexin (Cx) 43‐formed gap junctions and hemichannels mediate the communication between adjacent cells and cells and extracellular environment. Loss… read more here.
Keywords: junctions hemichannels; gap junctions; fracture healing; osteocytic connexin ... See more keywords
VEGF with AMD3100 endogenously mobilizes mesenchymal stem cells and improves fracture healing
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.24164
Abstract: A significant number of fractures develop non‐union. Mesenchymal stem cell (MSC) therapy may be beneficial, however, this requires cell acquisition, culture and delivery. Endogenous mobilization of stem cells offers a non‐invasive alternative. The hypothesis was… read more here.
Keywords: vegf amd3100; fracture healing; stem; stem cells ... See more keywords
The role of Meteorin‐like in skeletal development and bone fracture healing
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.25286
Abstract: Meteorin‐like protein (Metrnl), homologous to the initially identified neurotrophic factor Meteorin, is a secreted, multifunctional protein. Here we used mouse models to investigate Metrnl's role in skeletal development and bone fracture healing. During development Metrnl… read more here.
Keywords: bone; development; bone fracture; fracture healing ... See more keywords
[Mechanobiology of fracture healing part 1 : Principles].
Sign Up to like & getrecommendations! Published in 2017 at "Der Unfallchirurg"
DOI: 10.1007/s00113-016-0280-3
Abstract: It is undisputed that the stability of fracture fixation influences the fracture healing process; however, up until now the mechanical conditions which guide bone healing were unknown and it was therefore not possible to optimize… read more here.
Keywords: fracture; fracture fixation; tissue; bone ... See more keywords
[Mechanobiology of fracture healing part 2 : Relevance for internal fixation of fractures].
Sign Up to like & getrecommendations! Published in 2017 at "Der Unfallchirurg"
DOI: 10.1007/s00113-016-0281-2
Abstract: Clinical studies do not allow a quantitative correlation between stability of fracture fixation and outcome of bone healing. This limits the biomechanical improvement of fracture fixation techniques. The most practical quantitative parameter to describe the stability… read more here.
Keywords: stiffness; fixation; fracture; fracture fixation ... See more keywords