Deletion of a pseudogene within a fragile site triggers the oncogenic expression of the mitotic CCSER1 gene
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DOI: 10.26508/lsa.202101019
Abstract: Frequent deletions impacting the FRA4F fragile site leads to the oncogenic overexpression of the corresponding CCSER1 gene, through the deletion of the TMSB4XP8 pseudogene. The ensuing CCSER1 overexpression elicits mitotic instability, targetable with aurora kinase… read more here.
Keywords: ccser1 gene; gene; pseudogene; fragile site ... See more keywords
Recurrent alterations of the WW domain containing oxidoreductase gene spanning the common fragile site FRA16D in multiple myeloma and monoclonal gammopathy of undetermined significance.
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DOI: 10.3892/ol.2017.6672
Abstract: The putative tumor suppressor gene WW domain containing oxidoreductase (WWOX) spans a common fragile site (CFS) on chromosome 16q23.3. CFSs are regions of profound genomic instability and sites for genomic deletions in cancer cells. Therefore,… read more here.
Keywords: domain containing; methylation; containing oxidoreductase; multiple myeloma ... See more keywords