Sites of chromosomal instability in the context of nuclear architecture and function
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DOI: 10.1007/s00018-020-03698-2
Abstract: Chromosomal fragile sites are described as areas within the tightly packed mitotic chromatin that appear as breaks or gaps mostly tracing back to a loosened structure and not a real nicked break within the DNA… read more here.
Keywords: fragile sites; nuclear architecture; chromosomal instability; instability context ... See more keywords
High BrdU Sensitivity of Passeriformes Chromosomes: Conservation of BrdU-Sensitive Fragile Sites on Their Z Chromosomes during Evolution
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DOI: 10.1159/000499590
Abstract: Amongst 15 bird species, representative of 7 orders, recurrent breakages evocating the presence of fragile sites were detected in the chromosomes of the 5 species belonging to Passeriformes. These breaks appeared when 5-bromodeoxyuridine (BrdU) was… read more here.
Keywords: sensitive fragile; high brdu; brdu; fragile sites ... See more keywords
New Era of Mapping and Understanding Common Fragile Sites: An Updated Review on Origin of Chromosome Fragility
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DOI: 10.3389/fgene.2022.906957
Abstract: Common fragile sites (CFSs) are specific genomic loci prone to forming gaps or breakages upon replication perturbation, which correlate well with chromosomal rearrangement and copy number variation. CFSs have been actively studied due to their… read more here.
Keywords: common fragile; origin; cfss; fragile sites ... See more keywords
Fragile sites, chromosomal lesions, tandem repeats, and disease
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DOI: 10.3389/fgene.2022.985975
Abstract: Expanded tandem repeat DNAs are associated with various unusual chromosomal lesions, despiralizations, multi-branched inter-chromosomal associations, and fragile sites. Fragile sites cytogenetically manifest as localized gaps or discontinuities in chromosome structure and are an important genetic,… read more here.
Keywords: sites chromosomal; chromosomal lesions; repeat; fragile sites ... See more keywords