The Fragility of Statistically Significant Results in Randomized Clinical Trials for COVID-19
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DOI: 10.1001/jamanetworkopen.2022.2973
Abstract: Key Points Question In randomized clinical trials (RCTs) of COVID-19 that report statistically significant results, what is the fragility index, ie, the minimum number of participants who would need to have had a different outcome… read more here.
Keywords: clinical trials; significant results; fragility; randomized clinical ... See more keywords
Challenging endings: How telomeres prevent fragility
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DOI: 10.1002/bies.202100157
Abstract: It has become apparent that difficulties to replicate telomeres concern not only the very ends of eukaryotic chromosomes. The challenges already start when the replication fork enters the telomeric repeats. The obstacles encountered consist mainly… read more here.
Keywords: fragility; prevent fragility; telomeres prevent; challenging endings ... See more keywords
Lower Bone Density, Impaired Microarchitecture, and Strength Predict Future Fragility Fracture in Postmenopausal Women: 5‐Year Follow‐up of the Calgary CaMos Cohort
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3347
Abstract: The aim of this prospective study was to use high‐resolution peripheral quantitative computed tomography (HR‐pQCT) to determine if baseline skeletal parameters can predict incident fragility fracture in women and, secondly, to establish if women that… read more here.
Keywords: fragility; fracture; fragility fracture; bmd ... See more keywords
Incident Fragility Fractures Have a Long‐Term Negative Impact on Health‐Related Quality of Life of Older People: The Canadian Multicentre Osteoporosis Study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3666
Abstract: Although the short‐term impact of incident fragility fractures on health‐related quality of life (HRQL) of older people has been confirmed, we lack long‐term evidence. We explored the impact of incident fragility fractures on HRQL, among… read more here.
Keywords: fragility; older people; term; impact ... See more keywords
Real‐World Effectiveness of Anti‐Resorptive Treatment in Patients With Incident Fragility Fractures—The STORM Cohort—A Swedish Retrospective Observational Study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4498
Abstract: Results from real‐world evidence (RWE) from the largest healthcare region in Sweden show low uptake of antiresorptive (AR) treatment, but beneficial effect in those receiving treatment, especially for the composite outcome of hip fracture or… read more here.
Keywords: fracture; fragility; real world; treatment ... See more keywords
Methods to Study Repeat Fragility and Instability in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7306-4_28
Abstract: Trinucleotide repeats are common in the human genome and can undergo changes in repeat length. Expanded CAG repeats have been linked to over 14 human diseases and are considered hotspots for breakage and genomic rearrangement.… read more here.
Keywords: fragility; saccharomyces cerevisiae; study repeat; methods study ... See more keywords
Rush Fracture Liaison Service for capturing “missed opportunities” to treat osteoporosis in patients with fragility fractures
Sign Up to like & getrecommendations! Published in 2018 at "Osteoporosis International"
DOI: 10.1007/s00198-018-4559-9
Abstract: SummaryIn spite of being a public health problem of pandemic proportions, osteoporosis continues to be underdiagnosed and undertreated especially in older adults with fragility fractures. Confirmation of this hypothesis resulted in the development of a… read more here.
Keywords: fragility; fracture; fragility fracture; fracture liaison ... See more keywords
The Nottingham Spinal Health (NoSH) Study: a cohort study of patients hospitalised with vertebral fragility fractures
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DOI: 10.1007/s00198-019-05198-x
Abstract: Summary Patients hospitalised with vertebral fragility fractures were elderly, multimorbid and frail and lead to poor outcomes. Their hospital treatment needs to consider this alongside their acute fracture. A systematic organised model of care, such… read more here.
Keywords: fragility; patients hospitalised; study; care ... See more keywords
World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2021): Special Lecture Abstracts
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DOI: 10.1007/s00198-021-06109-9
Abstract: World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO‐IOF‐ESCEO 2021): Special Lecture Abstracts © International Osteoporosis Foundation and National Osteoporosis Foundation 2021 SL1 UCB-SPONSORED HONORARY LCTURE: WHERE ARE THE CRACKS? UNDERSTANDING THE NEEDS IN FRAGILITY… read more here.
Keywords: bone; fragility; loss; marrow ... See more keywords
World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2021): Educational Lectures Abstracts
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DOI: 10.1007/s00198-021-06110-2
Abstract: World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO‐IOF‐ESCEO 2021): Educational Lectures Abstracts © International Osteoporosis Foundation and National Osteoporosis Foundation 2021 EL1 DIETARY PATTERNS AND FRAC TUR E RISK S. Maggi1 1CNR Aging Branch-IN,… read more here.
Keywords: risk; pharma grade; fragility; esceo ... See more keywords
Prevalence and factors associated with osteoporosis and fragility fractures in patients with primary Sjögren syndrome
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DOI: 10.1007/s00296-020-04615-3
Abstract: This study aimed at determining socio-demographic and clinical factors of primary Sjögren syndrome (pSS) associated with osteoporosis (OP) and fragility fracture. SJOGRENSER is a cross-sectional study of patients with pSS, classified according to American European… read more here.
Keywords: fragility; age; fragility fractures; rheumatology ... See more keywords