The Fragility of Statistically Significant Results in Randomized Clinical Trials for COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.2973
Abstract: Key Points Question In randomized clinical trials (RCTs) of COVID-19 that report statistically significant results, what is the fragility index, ie, the minimum number of participants who would need to have had a different outcome… read more here.
Keywords: clinical trials; significant results; fragility; randomized clinical ... See more keywords
Atomistic Study of the Configurational Entropy and the Fragility of Supercooled Liquid GeTe
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202314264
Abstract: Phase‐change materials (PCMs) are an important family of alloys employed in non‐volatile memories and neuromorphic devices. These devices exploit the ability of PCMs to undergo rapid transitions between amorphous and crystalline phases at moderately high… read more here.
Keywords: temperature; liquid gete; configurational entropy; fragility ... See more keywords
Temperature dependence of polymer melt viscosity obtained based on DSC data and the consistency between thermodynamic and kinetic fragility
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Polymer Science"
DOI: 10.1002/app.55476
Abstract: The viscosity of the polymer melt has an impact on both the processing and properties of the product. However, conventional viscosity measurement methods have limitations such as strict testing conditions, large sample sizes, and long… read more here.
Keywords: temperature; fragility; polymer melt; polymer ... See more keywords
Challenging endings: How telomeres prevent fragility
Sign Up to like & getrecommendations! Published in 2021 at "BioEssays"
DOI: 10.1002/bies.202100157
Abstract: It has become apparent that difficulties to replicate telomeres concern not only the very ends of eukaryotic chromosomes. The challenges already start when the replication fork enters the telomeric repeats. The obstacles encountered consist mainly… read more here.
Keywords: fragility; prevent fragility; telomeres prevent; challenging endings ... See more keywords
Lower Bone Density, Impaired Microarchitecture, and Strength Predict Future Fragility Fracture in Postmenopausal Women: 5‐Year Follow‐up of the Calgary CaMos Cohort
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3347
Abstract: The aim of this prospective study was to use high‐resolution peripheral quantitative computed tomography (HR‐pQCT) to determine if baseline skeletal parameters can predict incident fragility fracture in women and, secondly, to establish if women that… read more here.
Keywords: fragility; fracture; fragility fracture; bmd ... See more keywords
Incident Fragility Fractures Have a Long‐Term Negative Impact on Health‐Related Quality of Life of Older People: The Canadian Multicentre Osteoporosis Study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3666
Abstract: Although the short‐term impact of incident fragility fractures on health‐related quality of life (HRQL) of older people has been confirmed, we lack long‐term evidence. We explored the impact of incident fragility fractures on HRQL, among… read more here.
Keywords: fragility; older people; term; impact ... See more keywords
Real‐World Effectiveness of Anti‐Resorptive Treatment in Patients With Incident Fragility Fractures—The STORM Cohort—A Swedish Retrospective Observational Study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4498
Abstract: Results from real‐world evidence (RWE) from the largest healthcare region in Sweden show low uptake of antiresorptive (AR) treatment, but beneficial effect in those receiving treatment, especially for the composite outcome of hip fracture or… read more here.
Keywords: fracture; fragility; real world; treatment ... See more keywords
Fragility of overactive bladder medication clinical trials: A systematic review
Sign Up to like & getrecommendations! Published in 2024 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.25468
Abstract: Overactive bladder (OAB) syndrome significantly impairs quality of life, often necessitating pharmacological interventions with associated risks. The fragility of OAB trial outcomes, as measured by the fragility index (FI: smallest number of event changes to… read more here.
Keywords: fragility overactive; bladder medication; fragility; overactive bladder ... See more keywords
Methods to Study Repeat Fragility and Instability in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7306-4_28
Abstract: Trinucleotide repeats are common in the human genome and can undergo changes in repeat length. Expanded CAG repeats have been linked to over 14 human diseases and are considered hotspots for breakage and genomic rearrangement.… read more here.
Keywords: fragility; saccharomyces cerevisiae; study repeat; methods study ... See more keywords
Rush Fracture Liaison Service for capturing “missed opportunities” to treat osteoporosis in patients with fragility fractures
Sign Up to like & getrecommendations! Published in 2018 at "Osteoporosis International"
DOI: 10.1007/s00198-018-4559-9
Abstract: SummaryIn spite of being a public health problem of pandemic proportions, osteoporosis continues to be underdiagnosed and undertreated especially in older adults with fragility fractures. Confirmation of this hypothesis resulted in the development of a… read more here.
Keywords: fragility; fracture; fragility fracture; fracture liaison ... See more keywords
The Nottingham Spinal Health (NoSH) Study: a cohort study of patients hospitalised with vertebral fragility fractures
Sign Up to like & getrecommendations! Published in 2019 at "Osteoporosis International"
DOI: 10.1007/s00198-019-05198-x
Abstract: Summary Patients hospitalised with vertebral fragility fractures were elderly, multimorbid and frail and lead to poor outcomes. Their hospital treatment needs to consider this alongside their acute fracture. A systematic organised model of care, such… read more here.
Keywords: fragility; patients hospitalised; study; care ... See more keywords