The Fragility of Statistically Significant Results in Randomized Clinical Trials for COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.2973
Abstract: Key Points Question In randomized clinical trials (RCTs) of COVID-19 that report statistically significant results, what is the fragility index, ie, the minimum number of participants who would need to have had a different outcome… read more here.
Keywords: clinical trials; significant results; fragility; randomized clinical ... See more keywords
The Fragility Index in HIV/AIDS Trials
Sign Up to like & getrecommendations! Published in 2019 at "Journal of General Internal Medicine"
DOI: 10.1007/s11606-019-05554-x
Abstract: D ear Editor: The recent report by Wayant and colleagues on the fragility index did not include the African randomized clinical trials on HIVand adult male circumcision. Analysis of these trials may provide insight into… read more here.
Keywords: fragility; hiv aids; three trials; index hiv ... See more keywords
Is APAF-CRT robust enough to change clinical practice?
Sign Up to like & getrecommendations! Published in 2022 at "European heart journal"
DOI: 10.1093/eurheartj/ehac092
Abstract: Kaur et al. raise the point of the fragility of results of APAF-CRT trial due to the relatively small population and consequently the small difference in the number of patients who died in the two… read more here.
Keywords: apaf crt; fragility; fragility index; robustness ... See more keywords
The Fragility of Statistically Significant Findings in Pediatric Critical Care Randomized Controlled Trials.
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Critical Care Medicine"
DOI: 10.1097/pcc.0000000000001922
Abstract: OBJECTIVES The Fragility Index measures the number of events on which the statistical significance of a result depends and has been suggested as an adjunct statistical assessment for interpretation of trial results. This study aimed… read more here.
Keywords: critical care; fragility; pediatric critical; fragility index ... See more keywords
Are results from randomized trials in anesthesiology robust or fragile? An analysis using the fragility index.
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Evidence-Based Healthcare"
DOI: 10.1097/xeb.0000000000000200
Abstract: AIM In anesthesiology, the findings from randomized controlled trials often underpin guidelines influencing clinical decision-making and therefore directly affect patient care. The aim of this study is to evaluate the fragility index and fragility quotient… read more here.
Keywords: fragility; fragility index; risk bias; anesthesiology ... See more keywords
The Fragility Index in peri‐operative randomised trials that reported significant mortality effects in adults
Sign Up to like & getrecommendations! Published in 2019 at "Anaesthesia"
DOI: 10.1111/anae.14656
Abstract: More than one million peri‐operative patients die each year. Thus, small improvements in peri‐operative care may save thousands of lives. However, clinicians need confidence in the robustness of trial findings. The Fragility Index may complement… read more here.
Keywords: peri operative; index; mortality; number ... See more keywords
The weakness of fragility index exposed in an analysis of the traumatic brain injury management guidelines: A meta-epidemiological and simulation study
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0237879
Abstract: Objectives To perform fragility index (FI) analysis on the evidence that forms the basis of the guidelines for the management of severe traumatic brain injury (TBI), and develop a deeper understanding of the pitfalls associated… read more here.
Keywords: traumatic brain; analysis; management; size ... See more keywords
The Fragility Index of Randomized Controlled Trials for Preterm Neonates
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.876366
Abstract: Background As a metric to determine the robustness of trial results, the fragility index (FI) is the number indicating how many patients would be required to reverse the significant results. This study aimed to calculate… read more here.
Keywords: randomized controlled; controlled trials; number; index randomized ... See more keywords