Characterization of fragment sizes, copy number aberrations and 4‐mer end motifs in cell‐free DNA of hepatocellular carcinoma for enhanced liquid biopsy‐based cancer detection
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13041
Abstract: Circulating cell‐free DNA (cfDNA) fragmentomics, which encompasses the measurement of cfDNA length and short nucleotide motifs at the ends of cfDNA molecules, is an emerging field for cancer diagnosis. The utilization of cfDNA fragmentomics for… read more here.
Keywords: end; cfdna; size; end motifs ... See more keywords
Optimal Physicochemical Properties of Antibody-Nanoparticle Conjugates for Improved Tumor Targeting.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced materials"
DOI: 10.1002/adma.202110305
Abstract: Tumor-targeted antibody (mAb)/fragment-conjugated nanoparticles (NPs) represent an innovative strategy for improving the local delivery of small molecules. However, the physicochemical properties of full mAb-NPs and fragment-NPs-that is, NP material, size, charge, as well as the… read more here.
Keywords: tumor; tumor uptake; mab nps; physicochemical properties ... See more keywords
Tying Up a Loose End: On the Role of the C‐Terminal CCHHRAG Fragment of the Metalloregulator CueR
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200290
Abstract: The transcriptional regulator CueR is activated by the binding of CuI, AgI, or AuI to two cysteinates in a near‐linear fashion. The C‐terminal CCHHRAG sequence in Escherichia coli CueR present potential additional metal binding ligands… read more here.
Keywords: cuer; terminal cchhrag; fragment; metal site ... See more keywords
Puckering the Planar Landscape of Fragments: Design and Synthesis of a 3D Cyclobutane Fragment Library
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200113
Abstract: Fragment‐based drug discovery (FBDD) has a growing need for unique screening libraries. The cyclobutane moiety was identified as an underrepresented yet attractive three‐dimensional (3D) scaffold. Synthetic strategies were developed via a key 3‐azido‐cyclobutanone intermediate, giving… read more here.
Keywords: fragments design; landscape fragments; fragment; cyclobutane ... See more keywords
Immunoaffinity Purification of the Glycosylated Extracellular Fragment of Mouse Plexin A2 Produced in a Mammalian Expression System.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6448-2_4
Abstract: Plexins are type I membrane proteins that function as receptors for semaphorins. All of the known plexins contain a large globular domain, termed the sema domain, in the N-terminal extracellular region, which interacts with semaphorins… read more here.
Keywords: fragment; purification; mouse plexin; extracellular fragment ... See more keywords
Higher serum levels of a cathepsin K–generated periostin fragment are associated with fractures in postmenopausal women with primary hyperparathyroidism: a pilot study
Sign Up to like & getrecommendations! Published in 2021 at "Osteoporosis International"
DOI: 10.1007/s00198-021-06018-x
Abstract: The only difference between fractured and non-fractured postmenopausal women with PHPT of same sex, age, and BMI was a significantly mean higher serum k-periostin level. K-periostin value was associated with fracture at any site (odds… read more here.
Keywords: fracture; periostin; serum; higher serum ... See more keywords
The Infrared spectrum of very large (periodic) systems: global versus fragment strategies—the case of three defects in diamond
Sign Up to like & getrecommendations! Published in 2018 at "Theoretical Chemistry Accounts"
DOI: 10.1007/s00214-018-2380-3
Abstract: The calculation of the full vibrational spectrum (Infrared or Raman) of very large systems (say larger than one thousand atoms) is not only very expensive, but also of relatively low interest, as in many (most… read more here.
Keywords: band; hbox; diamond; fragment ... See more keywords
Living in small spaces: Forest fragment characterization and its use by Philippine tarsiers (Tarsius syrichta Linnaeus, 1758) in Mindanao Island, Philippines
Sign Up to like & getrecommendations! Published in 2020 at "Primates"
DOI: 10.1007/s10329-020-00798-2
Abstract: The Philippine tarsier ( Tarsius syrichta ) is a charismatic species that is threatened by illegal hunting and deforestation. Although they occur in forest and disturbed habitats, ecological information about them is still considerably lacking,… read more here.
Keywords: philippine tarsiers; tarsius syrichta; mindanao island; forest fragment ... See more keywords
Synergistic effects of habitat configuration and land-use intensity shape the structure of bird assemblages in human-modified landscapes across three major neotropical biomes
Sign Up to like & getrecommendations! Published in 2021 at "Biodiversity and Conservation"
DOI: 10.1007/s10531-021-02275-8
Abstract: Maximizing biodiversity persistence in heterogeneous human-modified landscapes is hindered by the complex interactions between habitat quality and configuration of native and non-native habitats. Here we examined these complex interactions considering avian diversity across 26 sampling… read more here.
Keywords: configuration; bird; intensity; use intensity ... See more keywords
Application of a simple quantum chemical approach to ligand fragment scoring for Trypanosoma brucei pteridine reductase 1 inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-017-0035-4
Abstract: There is a need for improved and generally applicable scoring functions for fragment-based approaches to ligand design. Here, we evaluate the performance of a computationally efficient model for inhibitory activity estimation, which is composed only of multipole electrostatic… read more here.
Keywords: fragment; pteridine reductase; brucei pteridine; trypanosoma brucei ... See more keywords
Extending a Tandem Mass Spectral Library to Include MS2 Spectra of Fragment Ions Produced In-Source and MSn Spectra
Sign Up to like & getrecommendations! Published in 2017 at "Journal of The American Society for Mass Spectrometry"
DOI: 10.1007/s13361-017-1748-2
Abstract: AbstractTandem mass spectral library searching is finding increased use as an effective means of determining chemical identity in mass spectrometry-based omics studies. We previously reported on constructing a tandem mass spectral library that includes spectra… read more here.
Keywords: fragment ions; ms2 spectra; source; mass ... See more keywords