Total Synthesis of Poisonous Aconitum Alkaloids Empowered by a Fragment Coupling Strategy
Sign Up to like & getrecommendations! Published in 2021 at "ACS Central Science"
DOI: 10.1021/acscentsci.1c00887
Abstract: co-workers take on this considerable challenge, employing a fragment coupling strategy to synthesize (−)-talatisamine (1), (−)-liljestrandisine (2), and (−)-liljestrandinine (3). A series of highly chemoselective transformations was used to forge the polycyclic bridged skeleton of… read more here.
Keywords: fragment coupling; coupling strategy; total synthesis; strategy ... See more keywords
Palladium-Catalyzed Unimolecular Fragment Coupling of N-Allylamides via Elimination of Isocyanate.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c04527
Abstract: Transition metal-catalyzed unimolecular fragment coupling (UFC) is defined as processes that forge new chemical bonds through the extrusion of molecules, such as CO and CO2, and the subsequent recombination of the remaining fragments. Herein, we… read more here.
Keywords: elimination isocyanate; fragment; palladium catalyzed; unimolecular fragment ... See more keywords
Unified, Asymmetric Total Synthesis of the Asnovolins and Related Spiromeroterpenoids: A Fragment Coupling Approach.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c05366
Abstract: 3,5-Dimethylorsellinic acid (DMOA)-derived spiromeroterpenoids are a unique natural product family with attractive structures, unconventional stereochemistry, and potent biological activities. Herein, we report the first asymmetric total syntheses of the asnovolins, DMOA-derived spiromeroterpenoids. The spirocyclic skeleton… read more here.
Keywords: synthesis; stereochemistry; asymmetric total; unified asymmetric ... See more keywords
A convergent fragment coupling strategy to access quaternary stereogenic centers
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc07023e
Abstract: The formation of quaternary stereogenic centers via convergent fragment coupling is a longstanding challenge in organic synthesis. Here, we report a strategy for the formation of quaternary stereogenic centers in polycyclic systems based upon the… read more here.
Keywords: convergent fragment; stereogenic centers; coupling strategy; quaternary stereogenic ... See more keywords