How a Fragment Draws Attention to Selectivity Discriminating Features between the Related Proteases Trypsin and Thrombin.
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DOI: 10.1021/acs.jmedchem.0c01809
Abstract: In the S1 pocket, the serine proteases thrombin and trypsin commonly feature Asp189 and a Ala190Ser and Glu192Gln exchange. Nevertheless, thrombin cleaves peptide chains solely after Arg, and trypsin after Lys and Arg. Thrombin exhibits… read more here.
Keywords: draws attention; fragment draws; trypsin thrombin; selectivity ... See more keywords