Jumping from Fragment to Drug via Smart Scaffolds
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DOI: 10.1002/cmdc.202200092
Abstract: A focused drug repurposing approach is described where an FDAâapproved drug is rationally selected for biological testing based on structural similarities to a fragment compound found to bind a target protein by an NMR screen.… read more here.
Keywords: smart scaffolds; fda approved; drug; fragment drug ... See more keywords
Minibody-Based and scFv-Based Antibody Fragment-Drug Conjugates Selectively Eliminate GD2-Positive Tumor Cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021239
Abstract: Ganglioside GD2 is a well-established target expressed on multiple solid tumors, many of which are characterized by low treatment efficiency. Antibody-drug conjugates (ADCs) have demonstrated marked success in a number of solid tumors, and GD2-directed… read more here.
Keywords: tumor; fragment drug; drug conjugates; drug ... See more keywords