Synthesis of the C1–C13 fragment of eribulin mesylate
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.06.050
Abstract: Abstract Synthesis of the C1–C13 fragment of eribulin mesylate has been accomplished. It features a highly stereoselective construction of a trans-dihydropyran framework using three key reactions: (1) Sharpless epoxidation, (2) regioselective ring opening, and (3)… read more here.
Keywords: synthesis c13; fragment eribulin; c13 fragment; eribulin mesylate ... See more keywords
Stereoselective Synthesis of Northern Fragment of Eribulin Mesylate from d-Mannose
Sign Up to like & getrecommendations! Published in 2018 at "Synthesis"
DOI: 10.1055/s-0036-1591769
Abstract: Stereoselective synthesis of northern fragment of eribulin mesylate is reported by coupling of the C1–C13 fragment with the C28–C35 fragment. The key steps involved in this synthesis are butyllithium-facilitated coupling between sulfone and aldehyde, then… read more here.
Keywords: northern fragment; stereoselective synthesis; fragment eribulin; synthesis northern ... See more keywords