Molecular chaperone HSP70 prevents formation of inclusion bodies of the 25-kDa C-terminal fragment of TDP-43 by preventing aggregate accumulation
Sign Up to like & getrecommendations! Published in 2018 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-018-0930-1
Abstract: Transactive response DNA/RNA-binding protein 43-kDa (TDP-43) C-terminal fragments, such as a 25-kDa fragment (TDP-25), have been identified as a ubiquitinated and phosphorylated components of inclusion bodies (IBs) in motor neurons from amyotrophic lateral sclerosis patients.… read more here.
Keywords: inclusion bodies; hsp70; ibs; tdp ... See more keywords
TDP-35, a truncated fragment of TDP-43, induces dose-dependent toxicity and apoptosis in flies
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.338997
Abstract: TAR DNA-binding protein 43 (TDP-43) is an essential 414 amino acid protein that regulates multiple aspects of RNA biogenesis, processing, and transport. It localizes primarily in the nucleus, but abnormal translocation and accumulation in the… read more here.
Keywords: tdp induces; induces dose; tdp truncated; fragment tdp ... See more keywords