Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons
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DOI: 10.15252/embr.202153890
Abstract: Aggregation of the multifunctional RNA‐binding protein TDP‐43 defines large subgroups of amyotrophic lateral sclerosis and frontotemporal dementia and correlates with neurodegeneration in both diseases. In disease, characteristic C‐terminal fragments of ~25 kDa ("TDP‐25") accumulate in cytoplasmic… read more here.
Keywords: like inclusions; terminal fragments; sequester; gel like ... See more keywords