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Published in 2017 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-017-9515-3
Abstract: In this work we proposed a population physiologically-based pharmacokinetic (popPBPK) framework for quantifying and predicting inter-individual pharmacokinetic variability using the anti-HER2 monoclonal antibody (mAb) trastuzumab as an example. First, a PBPK model was developed to…
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Keywords:
variability;
inter individual;
quantifying predicting;
framework quantifying ... See more keywords
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Published in 2021 at "Methods in Ecology and Evolution"
DOI: 10.1111/2041-210x.13665
Abstract: The quantification of Hutchinson's n‐dimensional hypervolume has enabled substantial progress in community ecology, species niche analysis and beyond. However, most existing methods do not support a partitioning of the different components of hypervolume. Such a…
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Keywords:
distance;
ecology;
niche;
unifying framework ... See more keywords
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Published in 2018 at "Journal of Climate"
DOI: 10.1175/jcli-d-17-0719.1
Abstract: AbstractClimate variability and its response to increasing greenhouse gases are important considerations for impacts and adaptation. Modeling studies commonly assess projected changes in variabilit...
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Keywords:
covariance framework;
climate;
quantifying forced;
variability ... See more keywords