Ligand-based pharmacophore modelling, in silico virtual screening, molecular docking and molecular dynamic simulation study to identify novel Francisella tularensis ParE inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Papers"
DOI: 10.1007/s11696-020-01274-3
Abstract: ParE, a subunit of topoisomerase IV, is involved in the management of DNA topology and validated to be an attractive target for the development of antibacterial agents. Availability of the crystal structure of Francisella tularensis… read more here.
Keywords: tularensis; pare inhibitors; pharmacophore modelling; tularensis pare ... See more keywords
Rapid viability polymerase chain reaction method for detection of Francisella tularensis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of microbiological methods"
DOI: 10.1016/j.mimet.2019.105738
Abstract: Francisella tularensis, which causes potentially fatal tularemia, has been considered an attractive agent of bioterrorism and biological warfare due to its low infectious dose, reported environmental persistence, and ability to be transmitted to humans via… read more here.
Keywords: tularensis; rapid viability; method; polymerase chain ... See more keywords
Serological evidence of Francisella tularensis in febrile patients seeking treatment at remote hospitals, northeastern Kenya, 2014–2015
Sign Up to like & getrecommendations! Published in 2017 at "New Microbes and New Infections"
DOI: 10.1016/j.nmni.2017.05.015
Abstract: Tularaemia is a highly contagious infectious zoonosis caused by the bacterial agent Francisella tularensis. The aim of this study was to investigate the presence of antibodies to F. tularensis in febrile patients in northeastern Kenya.… read more here.
Keywords: tularensis; febrile patients; kenya; northeastern kenya ... See more keywords
CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10156-6
Abstract: Pulmonary immune control is crucial for protection against pathogens. Here we identify a pathway that promotes host responses during pulmonary bacterial infection; the expression of CD200 receptor (CD200R), which is known to dampen pulmonary immune… read more here.
Keywords: neutrophil niche; francisella tularensis; tularensis; cd200r ... See more keywords
Structural and functional studies of the metalloregulator Fur identify a promoter-binding mechanism and its role in Francisella tularensis virulence
Sign Up to like & getrecommendations! Published in 2018 at "Communications Biology"
DOI: 10.1038/s42003-018-0095-6
Abstract: Francisella tularensis is a Gram-negative bacterium causing tularaemia. Classified as possible bioterrorism agent, it may be transmitted to humans via animal infection or inhalation leading to severe pneumonia. Its virulence is related to iron homeostasis… read more here.
Keywords: tularensis; mechanism; virulence; role ... See more keywords
Efficacy of antibiotic medication strategy following a bioterrorist attack involving Francisella tularensis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Operational Research Society"
DOI: 10.1080/01605682.2021.1960909
Abstract: Francisella tularensis is a virulent bacterium which hijacks the host's immune response, turning cells usually tasked with killing foreign organisms as nutrient-rich receptacles for rapid multiplication. It is designated a Tier 1 Select Agent by… read more here.
Keywords: efficacy antibiotic; medication; francisella tularensis; antibiotic medication ... See more keywords
Arginine 58 is indispensable for proper function of the Francisella tularensis subsp. holarctica FSC200 HU protein, and its substitution alters virulence and mediates immunity against wild-type strain
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2132729
Abstract: ABSTRACT HU protein, a member of the nucleoid-associated group of proteins, is an important transcription factor in bacteria, including in the dangerous human pathogen Francisella tularensis. Generally, HU protein acts as a DNA sequence non-specific… read more here.
Keywords: tularensis subsp; fsc200; tularensis; subsp holarctica ... See more keywords
Francisella tularensis prevalence and load in Dermacentor reticulatus ticks in an endemic area in Central Europe
Sign Up to like & getrecommendations! Published in 2017 at "Medical and Veterinary Entomology"
DOI: 10.1111/mve.12229
Abstract: A total of 7778 host‐seeking adult Dermacentor reticulatus (Ixodida: Ixodidae) ticks were examined for the prevalence of Francisella tularensis holarctica (Thiotrichales: Francisellaceae) in a natural focus of tularaemia in the floodplain forest–meadow ecosystem along the… read more here.
Keywords: tularensis; prevalence; reticulatus; dermacentor reticulatus ... See more keywords
In Vitro Antibiotic Susceptibilities of Francisella tularensis Determined by Broth Microdilution following CLSI Methods
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00612-17
Abstract: ABSTRACT In vitro susceptibilities for 47 antibiotics were determined in 30 genetic diverse strains of Francisella tularensis by the broth microdilution method following Clinical and Laboratory Standards Institute (CLSI) methods. The F. tularensis strains demonstrated… read more here.
Keywords: tularensis; antibiotic susceptibilities; clsi methods; broth microdilution ... See more keywords
Protective Role for Macrophages in Respiratory Francisella tularensis Infection
Sign Up to like & getrecommendations! Published in 2017 at "Infection and Immunity"
DOI: 10.1128/iai.00064-17
Abstract: ABSTRACT Francisella tularensis causes lethal pneumonia following infection of the lungs by targeting macrophages for intracellular replication; however, macrophages stimulated with interferon gamma (IFN-γ) can resist infection in vitro. We therefore hypothesized that the protective… read more here.
Keywords: tularensis; infection; tularensis infection; mice ... See more keywords
Aim2 and Nlrp3 Are Dispensable for Vaccine-Induced Immunity against Francisella tularensis Live Vaccine Strain
Sign Up to like & getrecommendations! Published in 2021 at "Infection and Immunity"
DOI: 10.1128/iai.00134-21
Abstract: Francisella tularensis is a facultative, intracellular, Gram-negative bacterium that causes a fatal disease known as tularemia. Due to its extremely high virulence, ease of spread by aerosolization, and potential to be used as a bioterror… read more here.
Keywords: francisella tularensis; tularensis; aim2 nlrp3; immune responses ... See more keywords