The inhibitory effect in Fraxinellone on oxidative stress‐induced senescence correlates with AMP‐activated protein kinase‐dependent autophagy restoration
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26169
Abstract: As a natural metabolite of limonoids from Dictamnus dasycarpus, fraxinellone has been reported to be neuroprotective and anti‐inflammatory. However, its influence on cellular metabolism remains largely unknown. In the present study, we investigated the effect… read more here.
Keywords: effect fraxinellone; senescence; fraxinellone; oxidative stress ... See more keywords
Fraxinellone inhibits inflammatory cell infiltration during acute pancreatitis by suppressing inflammasome activation
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DOI: 10.1016/j.intimp.2019.01.043
Abstract: &NA; Inflammasomes promote the production of pro‐inflammatory cytokines, such as interleukin (IL)‐1&bgr; and IL‐18, which are the representative mediators of inflammation. Abnormal activation of inflammasomes leads to the development of inflammatory diseases such as acute… read more here.
Keywords: acute pancreatitis; inflammasome activation; infiltration; inflammatory cells ... See more keywords
Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death‐ligand 1 expression by reducing hypoxia‐inducible factor‐1&agr; and STAT3
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2018.08.004
Abstract: ABSTRACT Dictamnus dasycarpus is a traditional Chinese medicine thathas been commonly used in the treatment of cancer. Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective… read more here.
Keywords: agr; fraxinellone; programmed cell; expression ... See more keywords