β‐Octabromo‐ and β‐Octakis(trifluoromethyl)isocorroles: New Sterically Constrained Macrocyclic Ligands
Sign Up to like & getrecommendations! Published in 2017 at "ChemistryOpen"
DOI: 10.1002/open.201700035
Abstract: Abstract Presented herein is a study of the acid‐induced demetalation of two sterically hindered copper corroles, Cu β‐octabromo‐meso‐triphenylcorrole (Cu[Br8TPC]) and β‐octakis(trifluoromethyl)‐meso‐tris(p‐methoxyphenyl)corrole (Cu[(CF3)8TpOMePC]). Unlike reductive demetalation, which affords the free‐base β‐octabromocorrole, demetalation of Cu[Br8TPC] under non‐… read more here.
Keywords: octakis trifluoromethyl; cf3 8tpomepc; demetalation; free base ... See more keywords
Comparison of anti-influenza virus activity and pharmacokinetics of oseltamivir free base and oseltamivir phosphate
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Microbiology"
DOI: 10.1007/s12275-017-7371-x
Abstract: Influenza viruses are major human respiratory pathogens that cause high morbidity and mortality worldwide. Currently, prophylactic vaccines and therapeutic antiviral agents are used to prevent and control influenza virus infection. Oseltamivir free base (OSV-FB), a… read more here.
Keywords: oseltamivir; free base; influenza virus; virus ... See more keywords
Investigating the effects of amphipathic gastrointestinal compounds on the solution behaviour of salt and free base forms of clofazimine: An in vitro evaluation
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.09.012
Abstract: ABSTRACT Interactions between hydrophobic drugs and endogenous gastrointestinal substances have the potential to manipulate drug concentration in the human gastrointestinal system, and thus likely play an important role in determining the rate of absorption for… read more here.
Keywords: solution behaviour; salt; investigating effects; drug ... See more keywords
Preparation of double decker {Li3(Cl−)(Hhp)}22− dianions and H2TPCor− monoanions by deprotonation of free-base trithiododecaazahexaphyrin (H3Hhp) and triphenylcorrole (H3TPCor) macrocycles
Sign Up to like & getrecommendations! Published in 2021 at "Polyhedron"
DOI: 10.1016/j.poly.2021.115198
Abstract: Abstract Deprotonation of free-base [30]trithia-2,3,5,10,12,13,15,20,22,23,25,30-dodecaazahexaphyrin (hemihexaphyrazine, H3Hhp) and 5, 10, 15- triphenylcorrole (H3TPCor) macrocycles by an excess of lithium diethylamide, LiNEt2, in the presence of three equivalents of cryptand[2.2.2] has been studied. Crystallization of the… read more here.
Keywords: free base; h3hhp triphenylcorrole; hhp; deprotonation free ... See more keywords
Achieving exceptional creep resistance in rare-earth-free Mg-base alloys by engineering the shape, size and fraction of eutectic, particles and precipitates
Sign Up to like & getrecommendations! Published in 2019 at "Scripta Materialia"
DOI: 10.1016/j.scriptamat.2018.10.046
Abstract: Abstract Creep characterization of five rare-earth-free Mg-base alloys having distinct variations in microstructural features is investigated. Mg-base alloys exhibiting double minimum creep is observed for the first time. Lamellar eutectic microconstituent is responsible for this… read more here.
Keywords: base alloys; creep; free base; earth free ... See more keywords
Differential speciation of ferriprotoporphyrin IX in the presence of free base and diprotic 4-aminoquinoline antimalarial drugs
Sign Up to like & getrecommendations! Published in 2017 at "Solid State Sciences"
DOI: 10.1016/j.solidstatesciences.2017.01.007
Abstract: Abstract The crystal structures of the μ-propionato dimer and π–π dimer of ferriprotoporphyrin IX (Fe(III)PPIX) have been determined by single crystal X-ray diffraction (SCD). Both species were obtained in the presence of the synthetic 4-aminoquinoline… read more here.
Keywords: presence; dimer; iii ppix; free base ... See more keywords
Toward Better Characterization of a Free-Base Nicotine Fraction in e-Liquids and Aerosols.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00041
Abstract: Given that nicotine salts are a growing market, methods are needed to characterize nicotine forms in e-cigarette vaping products. By lowering the free-base nicotine fraction (αfb) in favor of protonated forms, the addition of organic… read more here.
Keywords: base nicotine; liquids aerosols; nicotine fraction; free base ... See more keywords
Free-Base Nicotine Is Nearly Absent in Aerosol from IQOS Heat-Not-Burn Devices, As Determined by 1H NMR Spectroscopy.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00076
Abstract: Heat-not-burn products, eg, I quit ordinary smoking (IQOS), are becoming popular alternative tobacco products. The nicotine aerosol protonation state has addiction implications due to differences in absorption kinetics and harshness. Nicotine free-base fraction (αfb) ranges… read more here.
Keywords: iqos; heat burn; spectroscopy; free base ... See more keywords
Hydrochloride Salt of the GABAkine KRM-II-81
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03029
Abstract: Imidazodiazepine (5-(8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazole[1,5-α][1,4]diazepin-3-yl) oxazole or KRM-II-81) is a potentiator of GABAA receptors (a GABAkine) undergoing preparation for clinical development. KRM-II-81 is active against many seizure and pain models in rodents, where it exhibits improved pharmacological properties… read more here.
Keywords: krm; hydrochloride salt; krm hcl; salt ... See more keywords
Colorimetric assay for the rapid determination of free-base nicotine in e-liquid
Sign Up to like & getrecommendations! Published in 2020 at "Analytical Methods"
DOI: 10.1039/c9ay02280e
Abstract: Nicotine exists in e-liquids primarily as the monoprotonated form and free-base form, the former is absorbed by the smoker relatively slowly and the latter is considered the bioavailable form of nicotine. Nowadays e-liquid manufacturers tend… read more here.
Keywords: liquid; base nicotine; base; free base ... See more keywords
Molecular structures, and optical and magnetic properties of free-base tetrapyrazinoporphyrazine in various reduction states
Sign Up to like & getrecommendations! Published in 2019 at "New Journal of Chemistry"
DOI: 10.1039/c9nj04775a
Abstract: The synthesis, and spectral and structural characterization of the novel radical anion and dianion salts of free-base tetrapyrazinoporphyrazine (H2TPyzPz) as well as studies of their magnetic properties have been described. read more here.
Keywords: molecular structures; magnetic properties; base tetrapyrazinoporphyrazine; free base ... See more keywords