Transition-Metal-Free Cleavage of C-C Triple Bonds in Aromatic Alkynes with S8 and Amides Leading to Aryl Thioamides.
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DOI: 10.1021/acs.orglett.8b00573
Abstract: A novel transition-metal-free cleavage reaction of C-C triple bonds in aromatic alkynes with S8 and amides furnishes aryl thioamides in moderate to excellent yields. The remarkable features of this thioamidation include the metal-free cleavage of… read more here.
Keywords: free cleavage; transition metal; aromatic alkynes; triple bonds ... See more keywords
Catalyst-free Cleavage of Amide and C-O Double Bond for the Diastereoselective Synthesis of Trifluoromethyl-Containing Dihydrooxazole Derivatives.
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DOI: 10.1021/acs.orglett.9b00522
Abstract: A novel and efficient cascade method has been developed for the diastereoselective preparation of trifluoromethyl-containing dihydrooxazoles in high yields. The reaction was applicable to electron-deficient, electron-rich arenes, heteroarenes, and alkyl groups. Control experiments were conducted… read more here.
Keywords: cleavage amide; free cleavage; trifluoromethyl containing; reaction ... See more keywords