Hydroxyethylcellulose as a methotrexate carrier in anticancer therapy
Sign Up to like & getrecommendations! Published in 2020 at "Investigational New Drugs"
DOI: 10.1007/s10637-020-00972-9
Abstract: Clinical and experimental cancer therapy is multifaceted; one such facet is the use of drug carriers. Drug carriers are various nano- and macromolecules, e.g., oligosaccharides, proteins, and liposomes. The present study aimed to verify the… read more here.
Keywords: free drug; hydroxyethylcellulose methotrexate; drug; carrier ... See more keywords
Incorporation of 2-amino-thiophene derivative in nanoparticles: enhancement of antifungal activity
Sign Up to like & getrecommendations! Published in 2020 at "Brazilian Journal of Microbiology"
DOI: 10.1007/s42770-020-00248-7
Abstract: The objective of this study was to evaluate the effects of nanoparticles (nanospheres and nanocapsules) of the promising antifungal 2-amino-thiophene (6CN10) and 6CN10 complexed with 2-hydroxypropyl-β-cyclodextrin (6CN10:HP-β-CD) in vitro and compared with free drug against… read more here.
Keywords: free drug; 6cn10 nanoparticles; drug; amino thiophene ... See more keywords
Physiologically Based Pharmacokinetic Modeling of 3 HIV Drugs in Combination and the Role of Lymphatic System after Subcutaneous Dosing. Part 1: Model for the Free-drug Mixture.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2021.10.007
Abstract: Drug-combination nanoparticles (DcNP) is a nano-formulation of multiple HIV drugs in one injectable. DcNP demonstrated long-acting pharmacokinetics (PK) for all drugs in the blood and lymphatic system of nonhuman primates (NHP). Long-acting is due to… read more here.
Keywords: hiv drugs; part; system; free drug ... See more keywords
Plasma Protein-Mediated Uptake and Contradictions to the Free Drug Hypothesis: A Critical Review.
Sign Up to like & getrecommendations! Published in 2023 at "Drug metabolism reviews"
DOI: 10.1080/03602532.2023.2195133
Abstract: According to the free drug hypothesis (FDH), only free, unbound drug is available to interact with biological targets. This hypothesis is the fundamental principle that continues to explain the vast majority of all pharmacokinetic and… read more here.
Keywords: plasma protein; protein mediated; drug hypothesis; mediated uptake ... See more keywords
The In Vitro Immunomodulatory Effects of Gold Nanocomplex on THP-1-Derived Macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/6031776
Abstract: Introduction This study is aimed at investigating the immunological response after treating THP-1 cells with gold nanorods conjugated with a phosphatidylinositol 3-kinase (PI3Kα) inhibitor. Methodology. Gold nanorods were synthesized and functionalized with cholesterol-PEG-SH moiety, and… read more here.
Keywords: gold nanorods; 00005 00005; expression; group ... See more keywords
In Vitro–In Vivo Correlation of Posaconazole–Amphotericin B Combination against Candida albicans: In Vitro Interacting Concentrations Are Associated with In Vivo Free Drug Levels
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Fungi"
DOI: 10.3390/jof9040434
Abstract: The in vitro/in vivo correlation of antifungal combination testing is necessary in order to assess the efficacy of combination regimens. We, therefore, attempted to correlate in vitro chequerboard testing of posaconazole (POS) and amphotericin B… read more here.
Keywords: vitro vivo; combination; vivo correlation; free drug ... See more keywords
Norfloxacin-Loaded Electrospun Scaffolds: Montmorillonite Nanocomposite vs. Free Drug
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics12040325
Abstract: Infections in nonhealing wounds remain one of the major challenges. Recently, nanomedicine approach seems a valid option to overcome the antibiotic resistance mechanisms. The aim of this study was the development of three types of… read more here.
Keywords: montmorillonite nanocomposite; free drug; chondroitin sulfate; drug ... See more keywords