Elevated cell‐free fetal DNA contributes to placental inflammation and antiangiogenesis via AIM2 and IFI16 during pre‐eclampsia
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DOI: 10.1002/jcp.29766
Abstract: Accumulated evidence has shown that pre‐eclampsia (PE) is related to both maternal and utero‐placental antiangiogenesis and inflammation. Remarkably, an elevated cell‐free fetal DNA (cffDNA) level has been found in maternal circulation; however, it remains unclear… read more here.
Keywords: elevated cell; aim2 ifi16; free fetal; dna ... See more keywords
Simulated confined placental mosaicism proportion (SCPMP) based on cell-free fetal DNA fraction enrichment can reduce false-positive results in non-invasive prenatal testing.
Sign Up to like & getrecommendations! Published in 2022 at "Prenatal diagnosis"
DOI: 10.1002/pd.6150
Abstract: OBJECTIVE To decrease the false-positive rate of NIPT using cell-free fetal DNA (cffDNA) fraction enrichment and the simulated confined placental mosaicism proportion (SCPMP) threshold application via cffDNA quantification. METHOD Using a cffDNA enrichment method, 303… read more here.
Keywords: free fetal; cell free; enrichment; false positive ... See more keywords
Content of Free Fetal DNA in Maternal Blood and Expression of DNA Recognition Receptors ZBP-1 in Placental Tissue in Preeclampsia and Preterm Labor
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-019-04665-z
Abstract: We evaluated the content of cell-free fetal DNA in maternal blood and expression of ZBP-1 receptors in the placental tissue of women with uncomplicated pregnancy, preeclampsia, and preterm labor. The study included 16 women with… read more here.
Keywords: free fetal; dna; preterm labor; preeclampsia ... See more keywords
Evolution of Down Syndrome Prenatal Screening Clinical Practices in Québec.
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DOI: 10.1016/j.jogc.2019.09.025
Abstract: OBJECTIVE Prenatal screening for Down syndrome (DS) has evolved greatly over the last decades with the improvement of first- and second-trimester serum screening and the introduction of cell-free fetal DNA. This study aimed to estimate… read more here.
Keywords: prenatal screening; free fetal; 2005 2007; diagnosis ... See more keywords
Research Progress of Cell-Free Fetal DNA in Non-Invasive Prenatal Diagnosis of Thalassemia.
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DOI: 10.1080/03630269.2023.2215446
Abstract: Thalassemia is a genetic disease that seriously affects the health of the fetus. At present, invasive prenatal diagnosis is the main method of thalassemia screening, but invasive prenatal diagnosis has the risk of fetal abortion.… read more here.
Keywords: cell free; invasive prenatal; thalassemia; free fetal ... See more keywords
Maternal Serum sEndoglin and Cell-Free Fetal DNA as Probable Markers of Preeclampsia: A Study in Single Center, Egypt
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DOI: 10.1080/08820139.2019.1578790
Abstract: ABSTRACT Background: This study was conducted to compare the levels of maternal serum soluble endoglin (sEng) and cell-free fetal DNA (cffDNA) in pregnant females with PE to normotensive pregnant ones, together with relating these levels… read more here.
Keywords: free fetal; study; maternal serum; cell free ... See more keywords
Prenatal Diagnosis of β-thalassemia with Cell-free Fetal DNA in Maternal Plasma.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the College of Physicians and Surgeons--Pakistan : JCPSP"
DOI: 10.29271/jcpsp.2019.05.483
Abstract: The aim of this study was to explore the feasibility of non-invasive prenatal genetic diagnosis of β-thalassemia with small fragments of cell-free fetal DNA (cffDNA) in peripheral blood of pregnant women. It was an observational… read more here.
Keywords: free fetal; diagnosis; cell free; fetal dna ... See more keywords
Cell-Free Fetal DNA and Non-Invasive Prenatal Diagnosis of Chromosomopathies and Pediatric Monogenic Diseases: A Critical Appraisal and Medicolegal Remarks
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm13010001
Abstract: Cell-free fetal DNA (cffDNA) analysis is a non-invasive prenatal diagnostic test with a fundamental role for the screening of chromosomic or monogenic pathologies of the fetus. Its administration is performed by fetal DNA detection in… read more here.
Keywords: dna; non invasive; cell free; invasive prenatal ... See more keywords
The Influence of Maternal Obesity on Cell-Free Fetal DNA and Blood Pressure Regulation in Pregnancies with Hypertensive Disorders
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DOI: 10.3390/medicina57090962
Abstract: Background and Objectives: obesity and blood pressure disorders are one of the main risk factors for antenatal, intra, postpartum, and neonatal complications. In preeclampsia (PE), the placental hypoxia leads to vascular endothelium dysfunction, cell necrosis,… read more here.
Keywords: free fetal; group; blood pressure; blood ... See more keywords
The Role of Cell-Free Fetal DNA as a Preventative Attempt to Decrease the Severity of Genetic Disorders: A Review
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DOI: 10.37506/mlu.v21i2.2638
Abstract: The development of prenatal diagnosis has developed very rapidly over decades. Prenatal screening is applied to a mother with high-risk pregnancy (threatening the life of the fetus), such as a too-old mother or a too-young… read more here.
Keywords: free fetal; cell free; genetic disorders; fetal dna ... See more keywords