Effects of Red Blood Cell Sickling on Right Ventricular Afterload in vivo
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Mechanics"
DOI: 10.1007/s11340-020-00669-3
Abstract: Background Hemolysis in sickle cell disease (SCD) releases cell free hemoglobin, which scavenges nitric oxide (NO), leading to pulmonary vascular vasoconstriction, increased pulmonary vascular resistance (PVR), and the development of PH. However, PVR is only… read more here.
Keywords: red blood; afterload; cell free; free hemoglobin ... See more keywords
Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.058
Abstract: BACKGROUND Increased endothelial permeability is central to shock and organ dysfunction in sepsis but therapeutics targeted to known mediators of increased endothelial permeability have been unsuccessful in patient studies. We previously reported that cell-free hemoglobin… read more here.
Keywords: ascorbate; endothelial permeability; cell free; permeability ... See more keywords
Hemoadsorption does not Affect Hemolysis During Cardiopulmonary Bypass.
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DOI: 10.1097/mat.0000000000000897
Abstract: Cardiopulmonary bypass (CPB) induces hemolysis, which manifests as plasma free hemoglobin. We investigated in a post hoc analysis of a single-center, blinded, controlled study whether the use of a novel hemoadsorption device (CytoSorb, CytoSorbents Europe… read more here.
Keywords: hemoadsorption; hemolysis; cardiopulmonary bypass; free hemoglobin ... See more keywords
Oxidized cell-free hemoglobin induces mitochondrial morphological changes and ROS production
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733895
Abstract: Background: During sepsis, red blood cells lyse and release cell-free hemoglobin (CFH) into the circulation causing vascular dysfunction and ROS production. The heme moiety of CFH is normally in the CFH2+ oxidative state but can… read more here.
Keywords: cell free; microscopy; production; physiology ... See more keywords