Rapid reduction of extremely high kappa free light chains in a patient with myeloma cast nephropathy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21619
Abstract: This report describes a patient with light chain myeloma and acute renal injury. Serum kappa free light chain (FLC) was extremely elevated, >33,000 mg/dL. Treatment with therapeutic plasma exchange (TPE) started day 2 for biopsy‐confirmed… read more here.
Keywords: cast nephropathy; kappa free; free light; tpe ... See more keywords
Kappa free light chains could predict early disease course in multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2019.02.001
Abstract: BACKGROUND Cerebrospinal fluid (CSF) kappa free light chains (KFLC) have been suggested as quantitative alternative to oligoclonal bands (OB) in multiple sclerosis (MS) diagnosis. Despite OB have been associated to poor disease prognosis, little is… read more here.
Keywords: sclerosis; free light; multiple sclerosis; light chains ... See more keywords
Analytical and clinical concordance of free light chain assay
Sign Up to like & getrecommendations! Published in 2019 at "Practical Laboratory Medicine"
DOI: 10.1016/j.plabm.2018.e00112
Abstract: The analysis of serum for the presence of free light chains has become an important adjunct to testing by serum protein electrophoresis (SPE) and immunofixation electrophoresis (IFE) [1]. The first commercial free light chain assays… read more here.
Keywords: free light; concordance; light; light chains ... See more keywords
Responses in multiple myeloma should be assigned according to serum, not urine, free light chain measurements
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia"
DOI: 10.1038/s41375-018-0339-y
Abstract: The most recent update to the International Myeloma Working Group consensus criteria places a strong emphasis on the need for more sensitive haematological markers of response driven by the success of novel therapies. One such… read more here.
Keywords: free light; myeloma; multiple myeloma; serum urine ... See more keywords
Elevated IgM and abnormal free light chain ratio are increased in relatives from high-risk chronic lymphocytic leukemia pedigrees
Sign Up to like & getrecommendations! Published in 2019 at "Blood Cancer Journal"
DOI: 10.1038/s41408-019-0186-8
Abstract: Abnormal serum immunoglobulin (Ig) free light chains (FLC) are established biomarkers of early disease in multiple B-cell lymphoid malignancies, including chronic lymphocytic leukemia (CLL). Heavy chains have also been shown to be biomarkers in plasma… read more here.
Keywords: risk; free light; lymphocytic leukemia; high risk ... See more keywords
Polyclonal serum free light chain elevation is associated with increased risk of monoclonal gammopathies
Sign Up to like & getrecommendations! Published in 2019 at "Blood Cancer Journal"
DOI: 10.1038/s41408-019-0210-z
Abstract: Monoclonal gammopathies (MG) constitute a spectrum of disorders starting from a monoclonal gammopathy of undetermined significance (MGUS) to active disease requiring therapy such as multiple myeloma. MG are characterized by proliferation of clonal plasma cells… read more here.
Keywords: risk; free light; monoclonal gammopathies; increased risk ... See more keywords
Revised free light chain reference intervals enhance risk stratification in monoclonal gammopathy of undetermined significance and reduce overdiagnosis
Sign Up to like & getrecommendations! Published in 2025 at "Blood Cancer Journal"
DOI: 10.1038/s41408-025-01289-7
Abstract: The free light chain (FLC) ratio is a critical part of risk stratification for monoclonal gammopathy of undetermined significance (MGUS). Recently, revised FLC reference intervals developed using the iStopMM cohort, accounting for age and renal… read more here.
Keywords: free light; risk stratification; reference intervals; risk ... See more keywords
Diffraction-free light droplets for axially-resolved volume imaging
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00042-w
Abstract: An ideal direct imaging system entails a method to illuminate on command a single diffraction-limited region in a generally thick and turbid volume. The best approximation to this is the use of large-aperture lenses that… read more here.
Keywords: free light; diffraction free; diffraction limited; volume ... See more keywords
Combined serum free light chain predicts prognosis in acute kidney injury following cardiovascular surgery
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2021.2013886
Abstract: Abstract Objectives Increased polyclonal free light chains (FLCs) are found in inflammatory conditions. Inflammation is recognized in the progression of acute kidney injury (AKI). This study was aimed to determine whether polyclonal combined FLC (cFLC)… read more here.
Keywords: cardiovascular surgery; following cardiovascular; free light; acute kidney ... See more keywords
Tixagevimab Plus Cilgavimab Does Not Affect the Interpretation of Electrophoretic and Free Light Chain Assays.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqac137
Abstract: OBJECTIVES There is concern that the anti-severe acute respiratory syndrome coronavirus 2 therapeutic monoclonal antibodies, used as preexposure prophylaxis in patients with multiple myeloma, may appear as a detectable monoclonal protein by electrophoretic methods, resulting… read more here.
Keywords: tixagevimab plus; interpretation; plus cilgavimab; free light ... See more keywords
B-319 Kappa and Lambda Free Light Chains Quantification in Serum Samples with 3 or 4 Monoclonal Components Detected by Serum Immunofixation
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Chemistry"
DOI: 10.1093/clinchem/hvae106.676
Abstract: Serum free light chain (FLC) quantification is a diagnostic criterion for monoclonal gammopathy. Oligoclonal expansion is defined when two or more small bands are detected in the gamma region of serum protein electrophoresis (SPEP) or… read more here.
Keywords: light chains; free light; flc ratio;