Catalyst-free regio- and chemoselective addition of secondary phosphine oxides to isoquinolines
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DOI: 10.1007/s11172-020-2874-8
Abstract: Isoquinolines react with secondary phosphine oxides without catalyst (70–75 °C, 10–15 h, without solvent or in MeCN) to chemo- and regioselectively form previously unknown diadducts, 1,3-bis(diorganylphosphoryl)-1,2,3,4-tetrahydroisoquinolines, in high yields (85–95%). read more here.
Keywords: free regio; secondary phosphine; phosphine oxides; regio chemoselective ... See more keywords
Additive-free regio- and diastereoselective construction of fully-substituted isoxazolidines employing diazo compounds
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DOI: 10.1039/c8qo01421c
Abstract: An efficient additive-free three-component access to densely functionalized isoxazolidines using diazo compounds, nitrosoarene, and allenic esters has been uncovered. read more here.
Keywords: additive free; free regio; diazo compounds; construction fully ... See more keywords