Predictive Screening for Inflammatory Disorders of Pregnancy Using Targeted Maternal Cell-Free RNA Assays: Proof-of-Principle Data from Large Animal and Human Cohorts
Sign Up to like & getrecommendations! Published in 2025 at "Reproductive Sciences"
DOI: 10.1007/s43032-025-01876-w
Abstract: The management and prevention of key inflammatory-associated pregnancy complications such as chorioamnionitis and pre-eclampsia is hampered by a lack of early gestation risk screening tools. In a proof-of-principle study we used targeted cell-free RNA analyses… read more here.
Keywords: proof principle; cell free; free rna; inflammatory ... See more keywords
Electrochemiluminescence Biosensor for Ascorbic Acid Based on Target Transformation of Cell-Free RNA Transcription System and Duplex-Specific Nuclease-Assisted Recycling Amplification.
Sign Up to like & getrecommendations! Published in 2024 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.4c04206
Abstract: A cell-free RNA transcription system had been coupled with electrochemiluminescence (ECL) detection technology for the first time to develop an ascorbic acid (AA, acting as a model target) biosensor. The biosensor is composed of single-stranded… read more here.
Keywords: chemistry; system; cell free; free rna ... See more keywords
Urine Cell-Free RNA vs Plasma Cell-Free RNA for Monitoring of Kidney Injury and Immune Complications
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DOI: 10.1093/clinchem/hvaf082
Abstract: Abstract Background There is increasing interest in the use of circulating cell-free RNA (cfRNA) in plasma as an analyte for diagnosing and monitoring disease. While it is known that cfRNA can also be isolated from… read more here.
Keywords: cfrna; cell free; free rna; cell ... See more keywords
Identification of RNU44 as an Endogenous Reference Gene for Normalizing Cell-Free RNA in Tuberculosis
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac540
Abstract: Abstract Background Normalization of cell-free RNA (cf-RNA) concentration can be affected by variable experimental conditions and thus impact the performance of their diagnostic potential. Our study aimed to identify appropriate endogenous reference genes for cf-RNA… read more here.
Keywords: tuberculosis; reference; cell free; endogenous reference ... See more keywords
Abstract LB178: Cell free RNA for prediction of PDAC in de novo symptomatic patients presenting for EUS-FNA
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb178
Abstract: Endoscopic ultrasound (EUS), the primary procedure for the diagnosis of pancreatic ductal adenocarcinoma (PDAC), the most lethal cancer, is invasive. We aim to develop a liquid biopsy approach using plasma cell-free messenger RNA to stratify… read more here.
Keywords: free rna; cell free; pdac; rna prediction ... See more keywords
Cell-Free RNA Signatures in Maternal Blood with Fetal Congenital Heart Disease
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DOI: 10.1161/circresaha.124.325024
Abstract: ingle ventricle heart defects (SVHDs) are the most severe type of congenital heart disease. 1 Through complex surgical procedures, patients with SVHDs can survive but ultimately have only one functional ventricle as either the left… read more here.
Keywords: maternal blood; cell free; heart; free rna ... See more keywords
Exploring the potential of cell-free RNA and Pyramid Scene Parsing Network for early preeclampsia screening
Sign Up to like & getrecommendations! Published in 2025 at "BMC Pregnancy and Childbirth"
DOI: 10.1186/s12884-025-07503-5
Abstract: Circulating cell-free RNA (cfRNA) is gaining recognition as an effective biomarker for the early detection of preeclampsia (PE). However, the current methods for selecting disease-specific biomarkers are often inefficient and typically one-dimensional. This study introduces… read more here.
Keywords: cfrna; cell free; pyramid scene; free rna ... See more keywords
Cell-free RNA as a Fetal Timekeeper.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical chemistry"
DOI: 10.1373/clinchem.2018.295527
Abstract: Cancer and fetal development share a lot. This is nothing new. The 19th century pathologist John Beard noted the similarities between a tumor and a trophoblast. Building on that, Lloyd Old, a pioneer in cancer… read more here.
Keywords: physics; cell free; rna fetal; blood ... See more keywords
Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2020.605219
Abstract: In recent years, there have been major advances in the application of non-invasive techniques to predict pregnancy-related complications, for example by measuring cell-free RNA (cfRNA) in maternal blood. In contrast to cell-free DNA (cfDNA), which… read more here.
Keywords: gestation; pregnancy; free rna; cell free ... See more keywords
Detection of Embryonic Trisomy 21 in the First Trimester Using Maternal Plasma Cell-Free RNA
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DOI: 10.3390/diagnostics12061410
Abstract: Prenatal trisomy 21 (T21) screening commonly involves testing a maternal blood sample for fetal DNA aneuploidy. It is reliable but poses a cost barrier to universal screening. We hypothesized maternal plasma RNA screening might provide… read more here.
Keywords: cell free; maternal plasma; rna; plasma cell ... See more keywords