Metal-free stereoselective annulation of quinolines with trifluoroacetylacetylenes and water: an access to fluorinated oxazinoquinolines.
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DOI: 10.1039/c7cc09725e
Abstract: Metal-free reaction between quinolines, aryltrifluoroacetylacetylenes and water at -18 °C-rt in MeCN resulted in stereoselective assembly of trifluoromethylated oxazinoquinolines with up to 99% yield that was essentially in contrast to a similar reaction with pyridines.… read more here.
Keywords: quinolines trifluoroacetylacetylenes; water; free stereoselective; stereoselective annulation ... See more keywords