Assessment of Progression-Free Survival as a Surrogate End Point of Overall Survival in First-Line Treatment of Ovarian Cancer
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DOI: 10.1001/jamanetworkopen.2019.18939
Abstract: This systematic review and meta-analysis evaluates whether progression-free survival is a validated surrogate end point for overall survival in patients with advanced ovarian cancer. read more here.
Keywords: end point; free survival; point overall; surrogate end ... See more keywords
A Dynamic Clinical Calculator for Estimating Conditional Recurrence-Free Survival After Total Neoadjuvant Therapy for Rectal Cancer and Either Surgery or Watch-and-Wait Management
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.33859
Abstract: Key Points Question Can a previously validated clinical calculator be adapted to estimate the risk of rectal cancer recurrence dynamically at different time points for patients who defer surgery after complete response to neoadjuvant therapy?… read more here.
Keywords: free survival; neoadjuvant therapy; recurrence; rectal cancer ... See more keywords
Analysis of a Machine Learning–Based Risk Stratification Scheme for Chronic Limb-Threatening Ischemia
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DOI: 10.1001/jamanetworkopen.2022.3424
Abstract: Key Points Question At the time of chronic limb-threatening ischemia (CLTI) diagnosis, how are increasing patient risk, wound severity, and degree of atherosclerotic occlusions associated with CLTI-free survival? Findings This cohort study analyzed nested cohort… read more here.
Keywords: clti free; free survival; threatening ischemia; chronic limb ... See more keywords
Analysis of Tumor Mutational Burden, Progression-Free Survival, and Local-Regional Control in Patents with Locally Advanced Non–Small Cell Lung Cancer Treated With Chemoradiation and Durvalumab
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DOI: 10.1001/jamanetworkopen.2022.49591
Abstract: Key Points Question Is tumor mutational burden (TMB) associated with outcomes among patients with locally advanced unresectable non–small cell lung cancer (NSCLC) treated with definitive chemoradiation and consolidative durvalumab? Findings In this cohort study of… read more here.
Keywords: locally advanced; free survival; durvalumab; progression free ... See more keywords
Relapse and Disease-Free Survival in Patients With Myelodysplastic Syndrome Undergoing Allogeneic Hematopoietic Cell Transplantation Using Older Matched Sibling Donors vs Younger Matched Unrelated Donors.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2021.6846
Abstract: Importance Matched sibling donors (MSDs) are preferred for allogeneic hematopoietic cell transplantation (allo-HCT) in myelodysplastic syndrome even if they are older. However, whether older MSDs or younger human leukocyte antigen-matched unrelated donors (MUDs) are associated… read more here.
Keywords: survival; free survival; allo hct; older msds ... See more keywords
Effect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.0122
Abstract: Importance Induction chemotherapy added to concurrent chemoradiotherapy significantly improves survival for patients with locoregionally advanced nasopharyngeal carcinoma, but the optimal induction regimen remains unclear. Objective To determine whether induction chemotherapy with paclitaxel, cisplatin, and capecitabine… read more here.
Keywords: nasopharyngeal carcinoma; free survival; induction chemotherapy; cisplatin ... See more keywords
Evaluation of Early vs Standard Liver Transplant for Alcohol-Associated Liver Disease.
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DOI: 10.1001/jamasurg.2021.3748
Abstract: Importance Traditionally, liver transplant (LT) for alcohol-associated liver disease (ALD) requires 6 months of abstinence. Although early LT before 6 months of abstinence has been associated with decreased mortality for decompensated ALD, this practice remains… read more here.
Keywords: early standard; free survival; relapse free; liver disease ... See more keywords
Developing a prediction model for disease‐free survival from upper urinary tract urothelial carcinoma in the Korean population
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DOI: 10.1002/cam4.2382
Abstract: In this study, we aimed to propose a validated prediction model for disease‐free survival (DFS) after radical nephroureterectomy (RNU) in a Korean population with upper urinary tract urothelial carcinoma (UTUC). read more here.
Keywords: disease free; upper urinary; prediction model; free survival ... See more keywords
Immune checkpoint inhibitors as first line in advanced melanoma: Evaluating progression‐free survival based on reconstructed individual patient data
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DOI: 10.1002/cam4.5067
Abstract: In patients with advanced melanoma, immune‐checkpoint inhibitors (ICIs) represent the mainstay for first line treatment. Recently, relatlimab+nivolumab was proposed as a new combination therapy. This review was aimed at summarizing the current data of effectiveness… read more here.
Keywords: advanced melanoma; free survival; checkpoint inhibitors; immune checkpoint ... See more keywords
Recurrence‐free survival dynamics following adjuvant chemotherapy for resected colorectal cancer: A systematic review of randomized controlled trials
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DOI: 10.1002/cam4.6884
Abstract: Several cytotoxic chemotherapies have demonstrated efficacy in improving recurrence‐free survival (RFS) following resection of Stage II–IV colorectal cancer (CRC). However, the temporal dynamics of response to such adjuvant therapy have not been systematically quantified. read more here.
Keywords: colorectal cancer; cancer; recurrence free; free survival ... See more keywords
Dual‐Phase Enhanced CT‐Derived Radiomics Nomogram for Progression‐Free Survival Prediction in Stage IV Lung Adenocarcinoma
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DOI: 10.1002/cam4.70473
Abstract: The objective is to establish a radiomics nomogram (Rad‐nomogram) using dual‐phase enhanced computed tomography (DPE‐CT) for the prediction of progression‐free survival (PFS) in patients diagnosed with stage IV lung adenocarcinoma (ADC). read more here.
Keywords: phase enhanced; radiomics nomogram; progression free; free survival ... See more keywords