Label-Free Target Identification Reveals the Anticancer Mechanism of a Rhenium Isonitrile Complex
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DOI: 10.3389/fchem.2022.850638
Abstract: Elucidation of the molecular mechanism of therapeutic agents and potential candidates is in high demand. Interestingly, rhenium-based complexes have shown a highly selective anticancer effect, only on cancer cells, unlike platinum-based drugs, such as cisplatin… read more here.
Keywords: label free; free target; mechanism; rhenium isonitrile ... See more keywords
Assay pH and critical reagent optimization in measuring concentrations of a monoclonal antibody and its target.
Sign Up to like & getrecommendations! Published in 2022 at "Bioanalysis"
DOI: 10.4155/bio-2021-0276
Abstract: Aim: To mitigate assay interference in the drug and target assays to support the development of monoclonal antibody REGN-Z. Results: Mild acidic assay conditions and capture and detection antibodies with different affinities and t1/2 under… read more here.
Keywords: monoclonal antibody; target; target assays; free target ... See more keywords