Linking Transthyretin-Binding Chemicals and Free Thyroid Hormones: In Vitro to In Vivo Extrapolation Based on a Competitive Binding Model.
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DOI: 10.1021/acs.est.3c01094
Abstract: Large numbers of pollutants competitively inhibit the binding between thyroid hormones and transthyretin (TTR) in vitro. However, the impact of this unintended binding on free thyroid hormones in vivo has not yet been characterized. Herein,… read more here.
Keywords: binding; ttr binding; free thyroid; binding chemicals ... See more keywords
Pregnancy outcomes are not altered by variation in thyroid function within the normal range in women free of thyroid disease.
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DOI: 10.1530/eje-17-0628
Abstract: OBJECTIVE In the recently revised guidelines on the management of thyroid dysfunction during pregnancy, treatment with thyroid hormone (LT4) is not recommended in women without thyroid autoimmunity (TAI) and TSH levels in the range 2.5-4.0 mIU/L,… read more here.
Keywords: pregnancy; free thyroid; within normal; women free ... See more keywords