Stability of Freeze-Dried Protein Formulations: Contributions of Ice Nucleation Temperature and Residence Time in the Freeze-Concentrate.
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DOI: 10.1016/j.xphs.2020.02.014
Abstract: Controlling ice nucleation at a fixed higher temperature results in larger ice crystals, which can reduce the ice/freeze-concentrate interface area where proteins can adsorb and degrade. Moreover, limited work has been done to address any… read more here.
Keywords: ice nucleation; temperature; freeze concentrate; stability ... See more keywords