Cholinergic system changes of falls and freezing of gait in Parkinson's disease
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DOI: 10.1002/ana.25430
Abstract: Postural instability and gait difficulties (PIGDs) represent debilitating disturbances in Parkinson's disease (PD). Past acetylcholinesterase positron emission tomography (PET) imaging studies implicate cholinergic changes as significant contributors to PIGD features. These studies were limited in… read more here.
Keywords: freezing gait; system changes; gait; cholinergic system ... See more keywords
Conditions Associated with On‐State Freezing of Gait
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DOI: 10.1002/mdc3.13445
Abstract: We previously described on -state freezing of gait ( on -FOG) as a rare gait phenotype in Parkinson ’ s disease (PD). 1 In on -FOG cases, levodopa dosage increases were associated with corres-ponding increases… read more here.
Keywords: state freezing; conditions associated; fog; freezing gait ... See more keywords
Freezing of Gait as a Complication of Pallidal Deep Brain Stimulation in DYT‐KMT2B Patients with Evidence of Striatonigral Degeneration
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DOI: 10.1002/mdc3.13519
Abstract: Mutations in KMT2B were fi rst identi fi ed in individuals with early-onset complex dystonia. 1 Since then, it is emerging as one of the most common causes of genetic childhood-onset dystonia. 2 Additional features… read more here.
Keywords: dyt kmt2b; deep brain; dystonia; brain stimulation ... See more keywords
The Gray Area of Freezing of Gait Annotation: A Guideline and Open‐Source Practical Tool
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DOI: 10.1002/mdc3.13556
Abstract: Freezing of gait, a disabling episodic symptom, is difficult to assess as the exact begin‐ and endpoint of an episode is not easy to specify. This hampers scientific and clinical progress. The current golden standard… read more here.
Keywords: gait annotation; annotation guideline; gray area; annotation ... See more keywords
Elastic Priming of Gait: An Effective Patient‐Created Strategy for Freezing of Gait
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DOI: 10.1002/mdc3.13594
Abstract: Freezing of gait (FOG) is a common symptom in Parkinson’s disease (PD) and is a significant cause of falls, disability, and reduced quality of life. Unfortunately, FOG is poorly understood pathophysiologically and remains difficult to… read more here.
Keywords: resistance bands; strategy; fog; created strategy ... See more keywords
Predicting the onset of freezing of gait: A longitudinal study
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DOI: 10.1002/mds.27208
Abstract: Background: Freezing of gait is a disabling symptom of Parkinson's disease that ultimately affects approximately 80% of patients, yet very little research has focused on predicting the onset of freezing of gait and tracking the… read more here.
Keywords: freezing gait; study; gait longitudinal; onset freezing ... See more keywords
Multitarget transcranial direct current stimulation for freezing of gait in Parkinson's disease
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DOI: 10.1002/mds.27300
Abstract: Background: Recent findings suggest that transcranial direct current stimulation of the primary motor cortex may ameliorate freezing of gait. However, the effects of multitarget simultaneous stimulation of motor and cognitive networks are mostly unknown. The… read more here.
Keywords: stimulation; current stimulation; freezing gait; multitarget transcranial ... See more keywords
Reply to: ‘Letter to the Editor on “A Randomized Controlled Trial of Exercise for Parkinsonian Individuals With Freezing of Gait”’
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DOI: 10.1002/mds.28292
Abstract: freezers based on NFOG-Q scores at baseline (TMR, 22.3 6.0; ARTI, 21.6 5.7), some of whom must have had FOG episodes lasting >30 seconds. Moreover, the Hoehn and Yahr stages in both groups ranged from… read more here.
Keywords: intervention; trial; fog ratio; freezing gait ... See more keywords
Dual Task Turning in Place: A Reliable, Valid, and Responsive Outcome Measure of Freezing of Gait
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DOI: 10.1002/mds.28887
Abstract: Freezing of gait (FOG) is a complex symptom in Parkinson's disease (PD) that is both elusive to elicit and varied in its presentation. These complexities present a challenge to measuring FOG in a sensitive and… read more here.
Keywords: dual task; turning place; place reliable; freezing gait ... See more keywords
Cerebellar theta burst stimulation does not improve freezing of gait in patients with Parkinson’s disease
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DOI: 10.1007/s00415-017-8479-y
Abstract: Freezing of gait (FOG) in Parkinson’s disease (PD) likely results from dysfunction within a complex neural gait circuitry involving multiple brain regions. Herein, cerebellar activity is increased in patients compared to healthy subjects. This cerebellar… read more here.
Keywords: freezing gait; theta burst; fog; gait ... See more keywords
Alterations in white matter network topology contribute to freezing of gait in Parkinson’s disease
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DOI: 10.1007/s00415-018-8846-3
Abstract: Freezing of gait (FOG) is a common symptom in advanced Parkinson’s disease (PD). Despite current advances, the neural mechanisms underpinning this disturbance remain poorly understood. To this end, we investigated the structural organisation of the… read more here.
Keywords: network; freezing gait; topology; parkinson disease ... See more keywords