Increased mtDNA mutation frequency in oocytes causes epigenetic alterations and embryonic defects
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DOI: 10.1093/nsr/nwac136
Abstract: Abstract Mitochondria are essential for female reproductive processes, yet the function of mitochondrial DNA (mtDNA) mutation in oocytes remains elusive. By employing an mtDNA mutator (Polgm) mouse model, we found the fetal growth retardation and… read more here.
Keywords: frequency oocytes; mtdna mutation; mutation frequency; increased mtdna ... See more keywords