Low‐frequency variants in mildly symptomatic vaccine breakthrough infections presents a doubled‐edged sword
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27726
Abstract: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants of concern (VOC) has raised questions regarding vaccine protection against SARS‐CoV‐2 infection, transmission, and ongoing virus evolution. Twenty‐three mildly symptomatic “vaccination breakthrough” infections were… read more here.
Keywords: breakthrough infections; frequency variants; low frequency; frequency ... See more keywords
414. The role of low-frequency variants in pre-eclampsia: Recent findings in a Finnish population
Sign Up to like & getrecommendations! Published in 2018 at "Pregnancy Hypertension"
DOI: 10.1016/j.preghy.2018.08.026
Abstract: The genetic basis of pre-eclampsia and its link with increased lifetime risk of cardiovascular diseases in women with a history of pre-eclampsia and children born from pre-eclamptic pregnancies are incompletely understood. Genetic factors have been… read more here.
Keywords: pre eclampsia; low frequency; pre; frequency variants ... See more keywords
Integrating DNA sequencing and transcriptomic data for association analyses of low-frequency variants and lipid traits.
Sign Up to like & getrecommendations! Published in 2020 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz314
Abstract: Transcriptome-wide association studies (TWAS) integrate GWAS and transcriptomic data to showcase their improved statistical power of identifying gene-trait associations while, importantly, offering further biological insights. TWAS have thus far focused on common variants as available… read more here.
Keywords: common variants; association; transcriptomic data; frequency variants ... See more keywords
A general approach to identify low-frequency variants within influenza samples collected during routine surveillance
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Genomics"
DOI: 10.1099/mgen.0.000867
Abstract: Influenza viruses exhibit considerable diversity between hosts. Additionally, different quasispecies can be found within the same host. High-throughput sequencing technologies can be used to sequence a patient-derived virus population at sufficient depths to identify low-frequency… read more here.
Keywords: surveillance; frequency variants; low frequency; influenza ... See more keywords
Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population
Sign Up to like & getrecommendations! Published in 2017 at "Hypertension"
DOI: 10.1161/hypertensionaha.117.09406
Abstract: Preeclampsia is a common pregnancy-specific vascular disorder characterized by new-onset hypertension and proteinuria during the second half of pregnancy. Predisposition to preeclampsia is in part heritable. It is associated with an increased risk of cardiovascular… read more here.
Keywords: fms related; related tyrosine; finnish population; frequency variants ... See more keywords
Population size influences the type of nucleotide variations in humans
Sign Up to like & getrecommendations! Published in 2019 at "BMC Genetics"
DOI: 10.1186/s12863-019-0798-9
Abstract: BackgroundIt is well known that the effective size of a population (Ne) is one of the major determinants of the amount of genetic variation within the population. However, it is unclear whether the types of… read more here.
Keywords: high frequency; size; population size; frequency variants ... See more keywords