Low‐frequency variants in mildly symptomatic vaccine breakthrough infections presents a doubled‐edged sword
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27726
Abstract: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants of concern (VOC) has raised questions regarding vaccine protection against SARS‐CoV‐2 infection, transmission, and ongoing virus evolution. Twenty‐three mildly symptomatic “vaccination breakthrough” infections were… read more here.
Keywords: breakthrough infections; frequency variants; low frequency; frequency ... See more keywords
414. The role of low-frequency variants in pre-eclampsia: Recent findings in a Finnish population
Sign Up to like & getrecommendations! Published in 2018 at "Pregnancy Hypertension"
DOI: 10.1016/j.preghy.2018.08.026
Abstract: The genetic basis of pre-eclampsia and its link with increased lifetime risk of cardiovascular diseases in women with a history of pre-eclampsia and children born from pre-eclamptic pregnancies are incompletely understood. Genetic factors have been… read more here.
Keywords: pre eclampsia; low frequency; pre; frequency variants ... See more keywords
Integrating DNA sequencing and transcriptomic data for association analyses of low-frequency variants and lipid traits.
Sign Up to like & getrecommendations! Published in 2020 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz314
Abstract: Transcriptome-wide association studies (TWAS) integrate GWAS and transcriptomic data to showcase their improved statistical power of identifying gene-trait associations while, importantly, offering further biological insights. TWAS have thus far focused on common variants as available… read more here.
Keywords: common variants; association; transcriptomic data; frequency variants ... See more keywords
A general approach to identify low-frequency variants within influenza samples collected during routine surveillance
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Genomics"
DOI: 10.1099/mgen.0.000867
Abstract: Influenza viruses exhibit considerable diversity between hosts. Additionally, different quasispecies can be found within the same host. High-throughput sequencing technologies can be used to sequence a patient-derived virus population at sufficient depths to identify low-frequency… read more here.
Keywords: surveillance; frequency variants; low frequency; influenza ... See more keywords
Abstract 4571: Ultra sensitive detection and quantification of low frequency variants in plasma using nRichDX extraction and PacBio SBB sequencing
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4571
Abstract: The detection and quantification of low frequency circulating tumor DNA (ctDNA) variants in plasma are essential for early cancer diagnosis and monitoring but remain challenging at variant allele frequencies (VAFs) below 1%. This study combines… read more here.
Keywords: detection; frequency variants; extraction; variants plasma ... See more keywords
Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population
Sign Up to like & getrecommendations! Published in 2017 at "Hypertension"
DOI: 10.1161/hypertensionaha.117.09406
Abstract: Preeclampsia is a common pregnancy-specific vascular disorder characterized by new-onset hypertension and proteinuria during the second half of pregnancy. Predisposition to preeclampsia is in part heritable. It is associated with an increased risk of cardiovascular… read more here.
Keywords: fms related; related tyrosine; finnish population; frequency variants ... See more keywords
Population size influences the type of nucleotide variations in humans
Sign Up to like & getrecommendations! Published in 2019 at "BMC Genetics"
DOI: 10.1186/s12863-019-0798-9
Abstract: BackgroundIt is well known that the effective size of a population (Ne) is one of the major determinants of the amount of genetic variation within the population. However, it is unclear whether the types of… read more here.
Keywords: high frequency; size; population size; frequency variants ... See more keywords