A frequent SNP in TRIM5α strongly enhances the innate immune response against LINE-1 elements
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DOI: 10.3389/fimmu.2023.1168589
Abstract: The intracellular restriction factor TRIM5α inhibits endogenous LINE-1 retroelements. It induces innate immune signaling cascades upon sensing of cytoplasmic LINE-1 complexes, thereby underlining its importance for protecting the human genome from harmful retrotransposition events. Here,… read more here.
Keywords: frequent snp; line elements; innate immune; line ... See more keywords