557 Determining the efficacy of ADCC by the 3D-EX ex vivo platform utilizing tumoroids of fresh patient tumor samples with intact tumor microenvironment
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DOI: 10.1136/jitc-2020-sitc2020.0557
Abstract: Background Antibody-dependent cell-mediated cytotoxicity (ADCC) is an effective tool where antibody-coated cells are targeted and killed by effector immune cells. The application of ADCC therapies has been expanded for both solid tumors as well as… read more here.
Keywords: immune; efficacy; oncology; fresh patient ... See more keywords
Abstract 6652: Employingex vivo3D-Screen technology for the development of rational combinations of immuno-oncology drugs in tumor organoids of fresh patient tissue
Sign Up to like & getrecommendations! Published in 2020 at "Immunology"
DOI: 10.1158/1538-7445.am2020-6652
Abstract: Introduction: Modern evaluation of novel immuno-oncological drug combinations requires a multi-faceted approach to accurately determine immune-cell activation and tumor cell viability. Additionally, retention of the intact tumor microenvironment through preparation of 3D tumor organoids is… read more here.
Keywords: tumor organoids; tumor cell; fresh patient; oncology ... See more keywords