A FRET‐Based Fluorescent Probe to Screen Anticancer Drugs, Inhibiting p73 Binding to MDM2
Sign Up to like & getrecommendations! Published in 2020 at "ChemBioChem"
DOI: 10.1002/cbic.202000660
Abstract: The protein p73 acts as a transcription factor, resulting in tumour suppression. MDM2, an oncogenic protein, can negatively influence p73‐mediated apoptosis by binding to p73 transactivation domains (TAD). Inhibition of the protein‐protein interaction between p73… read more here.
Keywords: protein; p73; fret probe; probe ... See more keywords
Highly sensitive detection of hepatitis C virus DNA by using a one-donor-four-acceptors FRET probe.
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DOI: 10.1016/j.talanta.2018.03.053
Abstract: Sensitive detection of Hepatitis C virus (HCV) DNA is critical to treat and prevent the propagation of hepatitis C diseases. Herein a FRET probe of One-Donor-Multi-Acceptors (D-mA) assembly is designed through the formation of triple-helix… read more here.
Keywords: detection; fret probe; dna; hepatitis ... See more keywords
Intrabody-based FRET probe to visualize endogenous histone acetylation
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DOI: 10.1038/s41598-019-46573-2
Abstract: Post-translational histone modifications are major regulators of gene expression. However, conventional immunoassays do not provide sufficient information regarding their spatial and temporal dynamic changes. Fluorescence/Förster resonance energy transfer (FRET)-based probes are capable of monitoring the… read more here.
Keywords: endogenous histone; histone acetylation; fret probe; probe ... See more keywords