Aquaporin 4 knockout increases complete freund's adjuvant-induced spinal central sensitization
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.01.004
Abstract: Growing evidence suggests a critical role of astrocytes for pain regulation. The water channel protein aquaporin 4 (AQP4), a functional regulator of astrocytes, is involved in various neurological disorders. However, the pathophysiological roles of AQP4… read more here.
Keywords: spinal central; central sensitization; complete freund; induced spinal ... See more keywords
Synthetic mycobacterial molecular patterns partially complete Freund’s adjuvant
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DOI: 10.1038/s41598-020-62543-5
Abstract: Complete Freund’s adjuvant (CFA) has historically been one of the most useful tools of immunologists. Essentially comprised of dead mycobacteria and mineral oil, we asked ourselves what is special about the mycobacterial part of this… read more here.
Keywords: molecular patterns; complete freund; freund adjuvant; synthetic mycobacterial ... See more keywords
Peptide emulsions in incomplete Freund’s adjuvant create effective nurseries promoting egress of systemic CD4+ and CD8+ T cells for immunotherapy of cancer
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DOI: 10.1136/jitc-2022-004709
Abstract: Water-in-oil emulsion incomplete Freund’s adjuvant (IFA) has been used as an adjuvant in preventive and therapeutic vaccines since its development. New generation, highly purified modulations of the adjuvant, Montanide incomplete seppic adjuvant (ISA)-51 and Montanide… read more here.
Keywords: cell; cd4; cancer peptide; incomplete freund ... See more keywords
Effects of different doses of complete Freund’s adjuvant on nociceptive behaviour and inflammatory parameters in polyarthritic rat model mimicking rheumatoid arthritis
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DOI: 10.1371/journal.pone.0260423
Abstract: Complete Freund’s adjuvant (CFA) has been used to develop the arthritic or inflammatory condition in the animal, but there is a lack of information concerning high CFA doses on nociceptive behaviour and inflammatory parameters. This… read more here.
Keywords: cfa; complete freund; inflammatory; rat ... See more keywords
Dehydrozingerone Alleviates Hyperalgesia, Oxidative Stress and Inflammatory Factors in Complete Freund’s Adjuvant-Induced Arthritic Rats
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DOI: 10.2147/dddt.s374827
Abstract: Purpose Rheumatoid arthritis (RA) is a chronic autoimmune disease with severe inflammatory responses. Dehydrozingerone (DHZ) is a potent bioactive compound found in the rhizomes of Zingiber officinale, and it has been reported as an excellent… read more here.
Keywords: factor; complete freund; oxidative stress; freund adjuvant ... See more keywords
Puerarin Attenuates Complete Freund’s Adjuvant-Induced Trigeminal Neuralgia and Inflammation in a Mouse Model via Sirt1-Mediated TGF-β1/Smad3 Inhibition
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DOI: 10.2147/jpr.s323588
Abstract: Background Puerarin, an active compound of radix puerariae, is a major compound used in Chinese herbal medicines and it has been well known for its pharmacological effects, including antioxidant, anti‑inflammatory, neuroprotective and cardioprotective properties. The… read more here.
Keywords: induced trigeminal; freund adjuvant; trigeminal neuralgia; complete freund ... See more keywords
Butin Attenuates Arthritis in Complete Freund’s Adjuvant-Treated Arthritic Rats: Possibly Mediated by Its Antioxidant and Anti-Inflammatory Actions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.810052
Abstract: The present research work was planned to evaluate the antioxidant and anti-inflammatory actions of butin in preventing complete Freund’s adjuvant-induced arthritis in rats. Adult Wistar rats (200–240 g) were segregated equally into four groups: Group… read more here.
Keywords: group; complete freund; freund adjuvant; anti inflammatory ... See more keywords
NLRP2 Is Overexpressed in Spinal Astrocytes at the Peak of Mechanical Pain Sensitivity during Complete Freund Adjuvant-Induced Persistent Pain
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DOI: 10.3390/ijms222111408
Abstract: Our earlier findings revealed that interleukin-1 receptor type-1 (IL-1R1) was overexpressed in spinal neurons, and IL-1R1-deficient mice showed significant attenuation of thermal and mechanical allodynia during the course of the Complete Freund adjuvant (CFA)-induced persistent… read more here.
Keywords: persistent pain; overexpressed spinal; complete freund; freund adjuvant ... See more keywords
Polyphenols from Dichrostachys cinerea Fruits Anti-Inflammatory, Analgesic, and Antioxidant Capacity in Freund’s Adjuvant-Induced Arthritic Rat Model
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DOI: 10.3390/molecules27175445
Abstract: Dichrostachys cinerea (L.) Wigth & Arn. (DC) is widely used in traditional medicine against several inflammatory diseases, especially rheumatoid arthritis, because of its antioxidant and anti-inflammatory effects. This study aimed to characterize the polyphenol-rich DC… read more here.
Keywords: antioxidant capacity; anti inflammatory; inflammatory; freund adjuvant ... See more keywords
Chrysin Is Immunomodulatory and Anti-Inflammatory against Complete Freund’s Adjuvant-Induced Arthritis in a Pre-Clinical Rodent Model
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DOI: 10.3390/pharmaceutics15041225
Abstract: Chrysin (5,7-dihydroxyflavone) has many pharmacological properties including anti-inflammatory actions. The objective of this study was to evaluate the anti-arthritic activity of chrysin and to compare its effect with the non-steroidal anti-inflammatory agent, piroxicam, against complete… read more here.
Keywords: complete freund; arthritis; anti inflammatory; model ... See more keywords
Evidence for Anti-Viral Effects of Complete Freund’s Adjuvant in the Mouse Model of Enterovirus Infection
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DOI: 10.3390/vaccines8030364
Abstract: Group B coxsackieviruses (CVBs) belonging to the genus, Enterovirus and contain six serotypes that induce various diseases, whose occurrence may involve the mediation of more than one serotype. We recently identified immunogenic epitopes within coxsackieviruses… read more here.
Keywords: anti viral; infection; group; complete freund ... See more keywords