Knockdown of the Wnt receptor Frizzled-1 (FZD1) reduces MDR1/P-glycoprotein expression in multidrug resistant leukemic cells and inhibits leukemic cell proliferation.
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DOI: 10.1016/j.leukres.2018.01.020
Abstract: Multidrug resistance (MDR) is a major obstacle to leukemia treatment. The Frizzled-1 (FZD1) Wnt receptor is involved in MDR in some solid cancers, but has rarely been reported to act in acute myeloid leukemia (AML).… read more here.
Keywords: frizzled fzd1; leukemic cells; wnt receptor; expression ... See more keywords