FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noac156
Abstract: Abstract Background We previously report that yes-associated protein (YAP), the core downstream effector of Hippo pathway, promotes the malignant progression of glioblastoma (GBM). However, although classical regulatory mechanisms of YAP are well explored, how YAP… read more here.
Keywords: siah1; progression; yap inducing; frk ... See more keywords
Hemifacial microsomia is linked a rare homozygous variant V162I in FRK and validated in zebrafish.
Sign Up to like & getrecommendations! Published in 2022 at "Oral diseases"
DOI: 10.1111/odi.14372
Abstract: OBJECTIVES Hemifacial microsomia (HFM) is a common birth defect involving the first and second branchial arch derivatives. Although several chromosomal abnormalities and causal gene variants have been identified, genetic etiologies in a majority of cases… read more here.
Keywords: hemifacial microsomia; cartilage; v162i frk; frk ... See more keywords