Frontal Cortex Proteome Perturbation after Juvenile Rat Secondhand Smoke Exposure
Sign Up to like & getrecommendations! Published in 2018 at "PROTEOMICS"
DOI: 10.1002/pmic.201800268
Abstract: Secondhand smoke remains a global concern for children's health. Epidemiological studies implicate exposure to secondhand smoke as a major risk factor for behavioral disorders, yet biological causation remains unclear. Model studies have mainly focused on… read more here.
Keywords: smoke exposure; frontal cortex; exposure; secondhand smoke ... See more keywords
Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-06015-2
Abstract: RATIONALE Accumulating evidence indicates critical involvement of mammalian target of rapamycin (mTOR) in the treatment of depressive disorders, epilepsy, and neurodegenerative disorders through its signal transduction mechanisms related to protein translation, autophagy, and synaptic remodeling.… read more here.
Keywords: rat frontal; mtor signaling; frontal cortex; mtor ... See more keywords
Memory and Learning Dysfunction Following Copper Toxicity: Biochemical and Immunohistochemical Basis
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0619-y
Abstract: The prototype disease of Cu toxicity in human is Wilson disease, and cognitive impairment is the presenting symptom of it. There is no study correlating Cu-induced excitotoxicity, apoptosis, and astrocytic reaction with memory dysfunction. We… read more here.
Keywords: dysfunction; memory learning; frontal cortex; group ... See more keywords
Downregulation of 14-3-3 Proteins in Alzheimer’s Disease
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DOI: 10.1007/s12035-019-01754-y
Abstract: One of the most abundant proteins expressed in the brain, 14-3-3 comprises about 1% of the brain’s total soluble proteins. The 14-3-3 isoforms bind to specific phosphoserine- and phosphothreonine-containing motifs found on a variety of… read more here.
Keywords: different isoforms; cortex; alzheimer disease; frontal cortex ... See more keywords
Ketamine for a Boost of Neural Plasticity: How, but Also When?
Sign Up to like & getrecommendations! Published in 2021 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2021.03.014
Abstract: Major depressive disorder affects millions of people and leads to debilitating symptoms. Although conventional antidepressants have been available and are often beneficial, they have several limitations, including a slow onset of action and an inadequate… read more here.
Keywords: ketamine; neural plasticity; frontal cortex; medial frontal ... See more keywords
Acute treatment with doxorubicin affects glutamate neurotransmission in the mouse frontal cortex and hippocampus
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research"
DOI: 10.1016/j.brainres.2017.07.003
Abstract: Doxorubicin (DOX) is a potent chemotherapeutic agent known to cause acute and long-term cognitive impairments in cancer patients. Cognitive function is presumed to be primarily mediated by neuronal circuitry in the frontal cortex (FC) and… read more here.
Keywords: treatment; glutamate neurotransmission; frontal cortex; dox ... See more keywords
Neuronal representations of reward-predicting cues and outcome history with movement in the frontal cortex.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108704
Abstract: Transformation of sensory inputs to goal-directed actions requires estimation of sensory-cue values based on outcome history. We conduct wide-field and two-photon calcium imaging of the mouse neocortex during classical conditioning with two cues with different… read more here.
Keywords: movement; frontal cortex; outcome history; reward predicting ... See more keywords
Abnormal structural connectivity between the basal ganglia, thalamus, and frontal cortex in patients with disorders of consciousness
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DOI: 10.1016/j.cortex.2017.02.011
Abstract: Consciousness loss in patients with severe brain injuries is associated with reduced functional connectivity of the default mode network (DMN), fronto-parietal network, and thalamo-cortical network. However, it is still unclear if the brain white matter… read more here.
Keywords: frontal cortex; ganglia thalamus; basal ganglia; thalamus frontal ... See more keywords
Modality-independent recruitment of inferior frontal cortex during speech processing in human infants
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Cognitive Neuroscience"
DOI: 10.1016/j.dcn.2018.10.002
Abstract: Despite increasing interest in the development of audiovisual speech perception in infancy, the underlying mechanisms and neural processes are still only poorly understood. In addition to regions in temporal cortex associated with speech processing and… read more here.
Keywords: inferior frontal; speech processing; cortex; speech ... See more keywords
Reduced effective connectivity between right parietal and inferior frontal cortex during audiospatial perception in neglect patients with a right-hemisphere lesion
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DOI: 10.1016/j.heares.2020.108052
Abstract: A lesion to the right hemisphere of the brain in humans commonly leads to perceptual neglect of the left side of the sensorium. The clinical observation that lesions to disparate cortical and subcortical areas converge… read more here.
Keywords: connectivity; neglect; frontal cortex; lesion ... See more keywords
Is damage to the pre-frontal cortex dormant until adolescence, or difficult to detect? Looking for keys that unlock executive functions in children in the wrong place.
Sign Up to like & getrecommendations! Published in 2017 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2017.07.031
Abstract: A range of functions can be negatively affected by pre-frontal cortex (PFC) injury, but observed behavioural and social changes are commonly linked to post-injury changes in executive function. Executive functioning is a complex neuropsychological construct… read more here.
Keywords: damage pre; pre frontal; adolescence; executive ... See more keywords