Identification and Preparation of a Novel Chemokine Receptor-Binding Domain in the Cytoplasmic Regulator FROUNT
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biotechnology"
DOI: 10.1007/s12033-017-0002-2
Abstract: FROUNT is a cytoplasmic protein that binds to the membrane-proximal C-terminal regions (Pro-Cs) of chemokine receptors, CCR2 and CCR5. The FROUNT–chemokine receptor interactions play a pivotal role in the migration of inflammatory immune cells, indicating… read more here.
Keywords: frount; preparation novel; chemokine receptor; chemokine ... See more keywords
Potential of the pharmacological inhibition of CCL2-CCR2 axis via targeting FROUNT to prevent the initiation and the progression of intracranial aneurysms in rats.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlae115
Abstract: Intracranial aneurysms (IAs) affect 1%-5% of the public and are a major cause of subarachnoid hemorrhage. Currently, there is no medical treatment to prevent the progression or rupture of IAs. Recent studies have defined IA… read more here.
Keywords: ccl2 ccr2; prevent; frount; inhibition ... See more keywords