Amelioration of type 1 diabetes by recombinant fructose-1,6-bisphosphate aldolase and cystatin derived from Schistosoma japonicum in a murine model
Sign Up to like & getrecommendations! Published in 2019 at "Parasitology Research"
DOI: 10.1007/s00436-019-06511-7
Abstract: Infection with helminth parasites or the administration of their antigens can prevent or attenuate autoimmune diseases. To date, the specific molecules that prime the amelioration are only limited. In this study, recombinant Schistosoma japonicum cystatin… read more here.
Keywords: amelioration; fructose bisphosphate; schistosoma japonicum; type diabetes ... See more keywords
The moonlighting protein fructose 1,6-bisphosphate aldolase as a potential vaccine candidate against Photobacterium damselae subsp. piscicida in Asian sea bass (Lates calcarifer).
Sign Up to like & getrecommendations! Published in 2021 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2021.104187
Abstract: Vaccination is the most effective, safe, and environmentally friendly method to prevent the outbreak of Photobacterium damselae subsp. piscicida (Phdp), a dangerous pathogen in aquaculture worldwide. Here, recombinant proteins of catalase, superoxide dismutase, isocitrate dehydrogenase,… read more here.
Keywords: damselae subsp; subsp piscicida; fructose bisphosphate; asian sea ... See more keywords
Structure-antifungal relationships and preventive effects of 1-(2,4-dihydroxyphenyl)-2-methylpropan-1-one derivatives as potential inhibitors of class-II fructose-1,6-bisphosphate aldolase.
Sign Up to like & getrecommendations! Published in 2019 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2019.05.016
Abstract: Emerging fungal phytodiseases are a food security threat and novel fungicides are in an urgent need. Herein, a series of isobutyrophenone derivatives were designed and synthesized. The derivatives exhibited excellent fungicidal activities against seven fungi.… read more here.
Keywords: class fructose; bisphosphate aldolase; structure; fructose bisphosphate ... See more keywords
Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02102
Abstract: Fructose-1,6-bisphosphate aldolase (FBA) represents an attractive new antifungal target. Here, we employed a structure-based optimization strategy to discover a novel covalent binding site (C292 site) and the first-in-class covalent allosteric inhibitors of FBA from Candida… read more here.
Keywords: bisphosphate aldolase; covalent; covalent inhibitors; covalent allosteric ... See more keywords
Network Basis for the Heat-Adapted Structural Thermostability of Bacterial Class II Fructose Bisphosphate Aldolase
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c00473
Abstract: The sufficient structural thermostability of a biological macromolecule is an overriding need for green nanoreactors and nanofactories to secure high activity. However, little is still known about what specific structural motif is responsible for it.… read more here.
Keywords: bisphosphate aldolase; structural thermostability; fructose bisphosphate; class fructose ... See more keywords
The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00889-7
Abstract: The enzyme fructose-bisphosphate aldolase occupies a central position in glycolysis and gluconeogenesis pathways. Beyond its housekeeping role in metabolism, fructose-bisphosphate aldolase has been involved in additional functions and is considered as a potential target for… read more here.
Keywords: francisella; fructose bisphosphate; bisphosphate aldolase; enzyme fructose ... See more keywords
Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01019-z
Abstract: Yeast and cancer cells share the unusual characteristic of favoring fermentation of sugar over respiration. We now reveal an evolutionary conserved mechanism linking fermentation to activation of Ras, a major regulator of cell proliferation in… read more here.
Keywords: fructose bisphosphate; fru1 6bisp; activation ras; yeast ... See more keywords
Development of fructose-1,6-bisphosphate aldolase enzyme peptide mimics as biocatalysts in direct asymmetric aldol reactions
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra06616a
Abstract: Novel asymmetric aldol reaction catalysing fructose-1,6-bisphosphate aldolase peptide mimics with secondary structural motifs. read more here.
Keywords: asymmetric aldol; bisphosphate aldolase; fructose bisphosphate; peptide mimics ... See more keywords
Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204407119
Abstract: Significance Cells respond to shifts in glucose supply or fluctuations in energetic demand through regulated changes in glycolytic metabolism. The rate at which glucose is converted to pyruvate is of considerable importance to cellular physiology;… read more here.
Keywords: fructose bisphosphate; single cells; biosensor; fluorescent biosensor ... See more keywords
Distinct plastid fructose bisphosphate aldolases function in photosynthetic and non-photosynthetic metabolism in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of experimental botany"
DOI: 10.1093/jxb/erab099
Abstract: Plastid metabolism is critical in both photoautotrophic and heterotrophic plant cells. In chloroplasts, fructose-1,6-bisphosphate aldolase (FBA) catalyses the formation of both fructose 1,6-bisphosphate and sedoheptulose 1,7-bisphosphate within the Calvin-Benson cycle. Three Arabidopsis genes, AtFBA1-AtFBA3, encode… read more here.
Keywords: fructose bisphosphate; arabidopsis; metabolism; plastid fructose ... See more keywords
Overexpression of aldolase, fructose‐bisphosphate C and its association with spheroid formation in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Pathology International"
DOI: 10.1111/pin.13200
Abstract: Colorectal cancer (CRC) is a leading cause of cancer‐related death worldwide. The spheroid colony formation assay is a useful method to identify cancer stem cells (CSCs). Using the DLD‐1 and WiDr CRC cell lines, we… read more here.
Keywords: cancer; fructose bisphosphate; spheroid; aldolase fructose ... See more keywords