Magnesium isoglycyrrhizinate ameliorates fructose-induced podocyte apoptosis through downregulation of miR-193a to increase WT1.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.05.016
Abstract: High fructose intake is a risk of glomerular podocyte dysfunction. Podocyte apoptosis has emerged as a major cause of podocyte loss, exacerbating proteinuria. Magnesium isoglycyrrhizinate (MgIG) is usually used as a hepatoprotective agent in clinic.… read more here.
Keywords: podocyte apoptosis; fructose induced; mir 193a; wt1 ... See more keywords
Effects of a novel isoflavonoid from the stem bark of Alstonia scholaris against fructose-induced experimental cataract.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of integrative medicine"
DOI: 10.1016/j.joim.2019.06.002
Abstract: OBJECTIVE The present study investigated the anticataract activity of a novel isoflavonoid, isolated from stem bark of Alstonia scholaris, against fructose-induced experimental cataract. METHODS The bioactivity of fractions extracted from A. scholaris, an isolated isoflavonoid… read more here.
Keywords: experimental cataract; novel isoflavonoid; group; fructose induced ... See more keywords
Protective effect of alpha-lipoic acid on progression of cataract formation in fructose-induced experimental cataract
Sign Up to like & getrecommendations! Published in 2017 at "PharmaNutrition"
DOI: 10.1016/j.phanu.2017.10.001
Abstract: Abstract Cataract is the leading cause of ocular blindness worldwide and exacerbated by various systemic disorders, including diabetes and hypertension. The present study was designed to investigate the protective effects of alpha-lipoic acid (LA) against… read more here.
Keywords: experimental cataract; induced experimental; fructose induced; cataract ... See more keywords
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2017.11.031
Abstract: In the present work, the effects and possible mechanisms of dioscin, one natural product from the famous vegetable Dioscoreae rhizoma (Shanyao in Chinese), against high fructose-induced renal injury in rats were tested. The results showed… read more here.
Keywords: inflammation; fructose induced; induced renal; lipid metabolism ... See more keywords
Administration of ursolic acid to new-born pups prevents dietary fructose-induced non-alcoholic fatty liver disease in Sprague Dawley rats
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Developmental Origins of Health and Disease"
DOI: 10.1017/s2040174420000124
Abstract: Abstract Overconsumption of fructose time dependently induces the development of non-alcoholic fatty liver disease (NAFLD). We investigated whether ursolic acid (UA) intake by new-born rats would protect against fructose-induced NAFLD. One hundred and seven male… read more here.
Keywords: fructose induced; fatty liver; disease; non alcoholic ... See more keywords
The role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-29336-3
Abstract: It is well-established that baroreflex sensitivity is essential for blood pressure control, and also plays a key role in the modulation of disease-induced metabolic alterations. In order to investigate the role of the baroreflex in… read more here.
Keywords: modulation; metabolic alterations; role baroreflex; fructose induced ... See more keywords
Dual effects of fructose on ChREBP and FoxO1/3α are responsible for AldoB up-regulation and vascular remodelling.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical science"
DOI: 10.1042/cs20160251
Abstract: Increased production of methylglyoxal (MG) in vascular tissues is one of the causative factors for vascular remodelling in different subtypes of metabolic syndrome, including hypertension and insulin resistance. Fructose-induced up-regulation of aldolase B (AldoB) contributes… read more here.
Keywords: vascular remodelling; foxo1; aldob regulation; fructose induced ... See more keywords
Chemical characterisation, hypoglycaemic and renoprotective effects of aqueous leaf extract of Limoniastrum guyonianum on fructose-induced metabolic syndrome in rats.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of physiology and biochemistry"
DOI: 10.1080/13813455.2020.1739715
Abstract: In the present study, we chemically characterised the aqueous leaf extract of Limoniastrum guyonianum by HPLC-TOF/MS and evaluated its effects on fructose-induced metabolic syndrome (MetS) in Wistar rats. MetS groups were given (10% w/v) fructose… read more here.
Keywords: aqueous leaf; leaf extract; fructose induced; metabolic syndrome ... See more keywords
Stevia residue extract alone and combination with allopurinol attenuate hyperuricemia in fructose-PO-induced hyperuricemic mice.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.13087
Abstract: The current project was designed to utilize flavonoids and chlorogenic acids enriched stevia residue extract (STVRE) against hyperuricemia (HU). The in vitro results showed that STVRE potently and synergistically inhibits Xanthine oxidase (XO) with allopurinol.… read more here.
Keywords: stevia residue; fructose induced; hyperuricemia; residue extract ... See more keywords
Carotenoids Inhibit Fructose-Induced Inflammatory Response in Human Endothelial Cells and Monocytes
Sign Up to like & getrecommendations! Published in 2020 at "Mediators of Inflammation"
DOI: 10.1155/2020/5373562
Abstract: Objective This research is aimed at determining the vascular health characteristics of carotenoids by evaluating their effect on excessive inflammatory response in endothelial and monocyte cells, the main factors of atherosclerosis. Methods Human umbilical vein… read more here.
Keywords: endothelial cells; fructose induced; inflammatory response; induced inflammatory ... See more keywords
Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Investigation"
DOI: 10.1172/jci89934
Abstract: Epidemiologic and animal studies implicate overconsumption of fructose in the development of nonalcoholic fatty liver disease, but the molecular mechanisms underlying fructose-induced chronic liver diseases remain largely unknown. Here, we have presented evidence supporting the… read more here.
Keywords: lipogenic transcription; fructose induced; transcription factor; chrebp ... See more keywords