The TKFC Ala185Thr variant, reported as ‘null’ for fructose metabolism, is fully active as triokinase
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14309
Abstract: TKFC‐encoded triokinase catalyses glyceraldehyde phosphorylation in fructose metabolism and favours lipogenesis in mice. In Tkfc knockouts or knockdowns, fructose oxidation predominates over lipogenesis. The highly prevalent human variant Ala185Thr‐Triokinase/FMN cyclase (TKFC) has been reported to… read more here.
Keywords: reported null; tkfc; triokinase; null fructose ... See more keywords
Dietary Fructose Metabolism By Splanchnic Organs: Size Matters.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.02.013
Abstract: The initial metabolism of fructose is thought to primarily take place in the liver. Using stable isotope labeling combined with tissue and arterio-venous sampling, Jang et al. (2018) demonstrate that in mice, the small intestine is… read more here.
Keywords: fructose metabolism; metabolism; dietary fructose; splanchnic organs ... See more keywords
Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.04.003
Abstract: Cancer metastasis accounts for the majority of cancer-related deaths and remains a clinical challenge. Metastatic cancer cells generally resemble cells of the primary cancer, but they may be influenced by the milieu of the organs… read more here.
Keywords: fructose metabolism; metabolic reprogramming; metabolism; liver ... See more keywords
Accelerated azo dye biodegradation and detoxification by Pseudomonas aeruginosa DDMZ1-2 via fructose co-metabolism
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Technology and Innovation"
DOI: 10.1016/j.eti.2021.101878
Abstract: Abstract Fructose was served as a promising co-substrate to facilitate the biodegradation and detoxification of refractory reactive black 5 (RB5) by a novel isolated strain DDMZ1-2. Analysis of 16S rRNA gene sequence confirmed its identity… read more here.
Keywords: fructose metabolism; biodegradation detoxification; strain;
AKR1B1-dependent fructose metabolism enhances malignancy of cancer cells
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DOI: 10.1038/s41418-024-01393-4
Abstract: Fructose metabolism has emerged as a significant contributor to cancer cell proliferation, yet the underlying mechanisms and sources of fructose for cancer cells remain incompletely understood. In this study, we demonstrate that cancer cells can… read more here.
Keywords: cancer; cancer cells; fructose metabolism; cell ... See more keywords
Evidence of fructose metabolism in colorectal cancer
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DOI: 10.1038/s41420-025-02745-w
Abstract: Colorectal cancer (CRC) represents a significant global health burden, contributing significantly to cancer-related mortality. The underlying genetic and metabolic underpinnings of CRC remain incompletely understood. In this study, we conducted a comprehensive investigation into metabolic… read more here.
Keywords: colorectal cancer; cancer; fructose metabolism; metabolism colorectal ... See more keywords
Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts
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DOI: 10.1111/joim.12993
Abstract: Mass extinctions occur frequently in natural history. While studies of animals that became extinct can be informative, it is the survivors that provide clues for mechanisms of adaptation when conditions are adverse. Here, we describe… read more here.
Keywords: metabolism common; fructose metabolism; common evolutionary; pathway ... See more keywords
Fructose metabolism in tumor endothelial cells promotes angiogenesis by activating AMPK signaling and mitochondrial respiration.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-1844
Abstract: Angiogenesis is vital for tumor growth and metastasis. Emerging evidence suggests that metabolic reprogramming in endothelial cells (ECs) may affect angiogenesis. Here, we showed that multiple regulators in the fructose metabolism pathway, especially fructose transporter… read more here.
Keywords: endothelial cells; mitochondrial respiration; fructose metabolism; angiogenesis ... See more keywords
Abstract 3084: Aldob regulates fructose metabolism to confer ferroptosis and immune response in colorectal cancer harboring microsatellite instability
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-3084
Abstract: Microsatellite instability (MSI) is a genetic alteration that occurs during cancer progression, specifically in colorectal cancer. Objective evidence demonstrates that colorectal cancer patients with MSI have better survival rates than those without MSI. Moreover, patients… read more here.
Keywords: colorectal cancer; cancer; fructose metabolism; microsatellite instability ... See more keywords
Fructose metabolism and metabolic disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci96702
Abstract: Increased sugar consumption is increasingly considered to be a contributor to the worldwide epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of its unique metabolic properties, the fructose component of… read more here.
Keywords: metabolism metabolic; fructose metabolism; metabolism; metabolic disease ... See more keywords
Do microglia metabolize fructose in Alzheimer’s disease?
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DOI: 10.1186/s12974-025-03401-x
Abstract: Alzheimer’s disease (AD) is an age-associated neurodegenerative disorder with a complex etiology. While emerging AD therapeutics can slow cognitive decline, they may worsen dementia in certain groups of individuals. Therefore, alternative treatments are much needed.… read more here.
Keywords: alzheimer disease; disease; microglia metabolize; fructose metabolism ... See more keywords