The TKFC Ala185Thr variant, reported as ‘null’ for fructose metabolism, is fully active as triokinase
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14309
Abstract: TKFC‐encoded triokinase catalyses glyceraldehyde phosphorylation in fructose metabolism and favours lipogenesis in mice. In Tkfc knockouts or knockdowns, fructose oxidation predominates over lipogenesis. The highly prevalent human variant Ala185Thr‐Triokinase/FMN cyclase (TKFC) has been reported to… read more here.
Keywords: reported null; tkfc; triokinase; null fructose ... See more keywords
Dietary Fructose Metabolism By Splanchnic Organs: Size Matters.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.02.013
Abstract: The initial metabolism of fructose is thought to primarily take place in the liver. Using stable isotope labeling combined with tissue and arterio-venous sampling, Jang et al. (2018) demonstrate that in mice, the small intestine is… read more here.
Keywords: fructose metabolism; metabolism; dietary fructose; splanchnic organs ... See more keywords
Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.04.003
Abstract: Cancer metastasis accounts for the majority of cancer-related deaths and remains a clinical challenge. Metastatic cancer cells generally resemble cells of the primary cancer, but they may be influenced by the milieu of the organs… read more here.
Keywords: fructose metabolism; metabolic reprogramming; metabolism; liver ... See more keywords
Accelerated azo dye biodegradation and detoxification by Pseudomonas aeruginosa DDMZ1-2 via fructose co-metabolism
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Technology and Innovation"
DOI: 10.1016/j.eti.2021.101878
Abstract: Abstract Fructose was served as a promising co-substrate to facilitate the biodegradation and detoxification of refractory reactive black 5 (RB5) by a novel isolated strain DDMZ1-2. Analysis of 16S rRNA gene sequence confirmed its identity… read more here.
Keywords: fructose metabolism; biodegradation detoxification; strain;
Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Internal Medicine"
DOI: 10.1111/joim.12993
Abstract: Mass extinctions occur frequently in natural history. While studies of animals that became extinct can be informative, it is the survivors that provide clues for mechanisms of adaptation when conditions are adverse. Here, we describe… read more here.
Keywords: metabolism common; fructose metabolism; common evolutionary; pathway ... See more keywords
Fructose metabolism in tumor endothelial cells promotes angiogenesis by activating AMPK signaling and mitochondrial respiration.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-1844
Abstract: Angiogenesis is vital for tumor growth and metastasis. Emerging evidence suggests that metabolic reprogramming in endothelial cells (ECs) may affect angiogenesis. Here, we showed that multiple regulators in the fructose metabolism pathway, especially fructose transporter… read more here.
Keywords: endothelial cells; mitochondrial respiration; fructose metabolism; angiogenesis ... See more keywords
Fructose metabolism and metabolic disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci96702
Abstract: Increased sugar consumption is increasingly considered to be a contributor to the worldwide epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of its unique metabolic properties, the fructose component of… read more here.
Keywords: metabolism metabolic; fructose metabolism; metabolism; metabolic disease ... See more keywords
Computational Modeling of Fructose Metabolism and Development in NAFLD
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00762
Abstract: Non-alcohol fatty liver disease (NAFLD) is a common disorder that has increased in prevalence 20-fold over the last three decades. It covers a spectrum of conditions resulting from excess lipid accumulation in the liver without… read more here.
Keywords: computational modeling; model; development nafld; fructose metabolism ... See more keywords
Endogenous Fructose Metabolism Could Explain the Warburg Effect and the Protection of SGLT2 Inhibitors in Chronic Kidney Disease
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.694457
Abstract: Chronic low-grade inflammation underlies the pathogenesis of non-communicable diseases, including chronic kidney diseases (CKD). Inflammation is a biologically active process accompanied with biochemical changes involving energy, amino acid, lipid and nucleotides. Recently, glycolysis has been… read more here.
Keywords: kidney; fructose metabolism; chronic kidney; warburg effect ... See more keywords
Fructose metabolism and its role in pig production: A mini-review
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.922051
Abstract: Epidemiological studies have shown that excessive intake of fructose is largely responsible for the increasing incidence of non-alcoholic fatty liver, obesity, and diabetes. However, depending on the amount of fructose consumption from diet, the metabolic… read more here.
Keywords: role; fructose metabolism; metabolism; pig production ... See more keywords
Fructose Metabolism and Cardiac Metabolic Stress
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.695486
Abstract: Cardiovascular disease is one of the leading causes of mortality in diabetes. High fructose consumption has been linked with the development of diabetes and cardiovascular disease. Serum and cardiac tissue fructose levels are elevated in… read more here.
Keywords: cardiac metabolic; metabolic stress; stress; fructose metabolism ... See more keywords