Introducing urea into tirapazamine derivatives to enhance anticancer therapy
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DOI: 10.1093/nsr/nwae038
Abstract: ABSTRACT Tirapazamine (TPZ) has been approved for multiple clinical trials relying on its excellent anticancer potential. However, as a typical hypoxia-activated prodrug (HAP), TPZ did not exhibit survival advantages in Phase III clinical trials when… read more here.
Keywords: tirapazamine; ft11 tpzp; tpz; hypoxia ... See more keywords