Pharmacokinetics of Tenofovir Alafenamide, Tenofovir, and Emtricitabine Following Administration of Coformulated Emtricitabine/Tenofovir Alafenamide in Healthy Japanese Subjects
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DOI: 10.1002/cpdd.623
Abstract: A fixed‐dose combination of tenofovir alafenamide (TAF) and emtricitabine (FTC) is available in 2 tablet strengths in Japan (FTC/TAF 200/10 mg and FTC/TAF 200/25 mg). These are used once daily in combination with other antiretroviral… read more here.
Keywords: ftc taf; treatment; tenofovir alafenamide; taf 200 ... See more keywords
Comparison of the design and methodology of Phase 3 clinical trials of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) and dolutegravir-based dual therapy (DTG) in HIV: a systematic review of the literature
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Anti-infective Therapy"
DOI: 10.1080/14787210.2023.2149490
Abstract: ABSTRACT Introduction Current recommended antiretroviral regimens include a combination of two (dual; DT) or three (triple; TT) antiretroviral drugs. This study aims to determine whether the quality of evidence from clinical trials of dolutegravir (dolutegravir/lamivudine… read more here.
Keywords: clinical trials; methodology; ftc taf; bic ftc ... See more keywords
Randomized Trial Evaluating the Neurotoxicity of Dolutegravir/Abacavir/Lamivudine and Its Reversibility After Switching to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide: GESIDA 9016
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DOI: 10.1093/ofid/ofaa482
Abstract: Abstract Background Despite evidence shown of dolutegravir (DTG)-related neurotoxicity, which may be more common when combined with abacavir (ABC), its reversibility has not been explored in a clinical trial. Methods We conducted a randomized, multicenter,… read more here.
Keywords: ftc taf; cobi ftc; neuropsychiatric symptoms; evg cobi ... See more keywords
Incidence and Severity of Drug Interactions Before and After Switching Antiretroviral Therapy to Bictegravir/Emtricitabine/Tenofovir Alafenamide in Treatment-Experienced Patients
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DOI: 10.1093/ofid/ofaa625
Abstract: Abstract Background Switching antiretroviral therapy (ART) in people with HIV (PWH) can influence their risk for drug–drug interactions (DDIs). The purpose of this study was to assess changes in the incidence and severity of DDIs… read more here.
Keywords: bic ftc; ftc taf; drug; art ... See more keywords
Bictegravir/emtricitabine/tenofovir alafenamide plus doravirine in highly treatment-experienced men with multidrug-resistant HIV
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DOI: 10.1097/qad.0000000000003513
Abstract: Objective: To evaluate the safety and efficacy of switching highly treatment-experienced people with HIV (HTE PWH) from rilpivirine/emtricitabine/tenofovir alafenamide (RPV/FTC/TAF) plus dolutegravir (DTG) to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) plus doravirine (DOR). A pharmacokinetic (PK) analysis was… read more here.
Keywords: taf plus; emtricitabine tenofovir; ftc taf; treatment ... See more keywords
Forgiveness of INSTI-Containing Regimens at Drug Concentrations Simulating Variable Adherence In Vitro
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DOI: 10.1128/aac.02038-21
Abstract: The integrase strand transfer inhibitor (INSTI)-based regimens bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF), dolutegravir (DTG)+FTC/TAF, DTG/lamivudine (3TC), and DTG/rilpivirine (RPV) are all approved for treatment of HIV-infected patients, with various limitations. Here, time to in vitro viral breakthrough… read more here.
Keywords: drug; resistance; ftc taf; dtg ... See more keywords
Switching to a Bictegravir Single Tablet Regimen in Elderly People Living with HIV-1: Data Analysis from the BICTEL Cohort
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DOI: 10.3390/diagnostics12010076
Abstract: Bictegravir/emtricitabine/tenofovir alafenamide fumarate (BIC/FTC/TAF) is a recommended once-daily single tablet regimen for the treatment of people living with HIV-1 (PLWH). We aimed to assess efficacy, safety and tolerability of BIC/FTC/TAF among PLWH, with a specific… read more here.
Keywords: single tablet; value; bic ftc; tablet regimen ... See more keywords