C9orf72 expansions are the most common cause of genetic frontotemporal dementia in a Southeast Asian cohort
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51744
Abstract: Frontotemporal dementia (FTD) encompasses a spectrum of neurodegenerative disorders, including behavioural variant FTD (bvFTD), semantic variant primary progressive aphasia (svPPA) and non‐fluent variant PPA (nfvPPA). While a strong genetic component is implicated in FTD, genetic… read more here.
Keywords: southeast asian; frontotemporal dementia; c9orf72 expansions; ftd ... See more keywords
Classifying Alzheimer's disease and frontotemporal dementia using machine learning with cross‐sectional and longitudinal magnetic resonance imaging data
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26205
Abstract: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are common causes of dementia with partly overlapping, symptoms and brain signatures. There is a need to establish an accurate diagnosis and to obtain markers for disease tracking.… read more here.
Keywords: machine; alzheimer disease; ftd; cross sectional ... See more keywords
Improved chemoradiation treatment using trifluridine in human colorectal cancer cells in vitro.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.044
Abstract: We aimed to assess the combined effect of trifluridine (FTD) and ionizing radiation (IR) on colorectal cancer cells in vitro. Colorectal cancer cells, HT-29, HCT-15, and HCT 116, showing low, medium, and high sensitivity to… read more here.
Keywords: treatment; colorectal cancer; ftd; cancer cells ... See more keywords
The olfactory bulb proteotype differs across frontotemporal dementia spectrum.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2019.04.011
Abstract: Mild olfactory dysfunction has been observed in frontotemporal dementias (FTD). However, the underlying molecular mechanisms associated to this deficit are poorly understood. We applied quantitative proteomics to analyze pathological effects on the olfactory bulb (OB)… read more here.
Keywords: ftd; ftld tdp43; olfactory bulb; protein kinase ... See more keywords
Driving and depression: Health professional's perspectives in Ireland
Sign Up to like & getrecommendations! Published in 2017 at "Journal of transport and health"
DOI: 10.1016/j.jth.2017.09.003
Abstract: Abstract Background Assessing the fitness to drive (FTD) of individuals with depression is important for their safety and the safety of other road users. Although medical fitness to drive (FTD) guidelines exist in Ireland little… read more here.
Keywords: consultant psychiatrists; depression; general practitioners; ftd ... See more keywords
Using diffusion tensor imaging to detect cortical changes in fronto-temporal dementia subtypes
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68118-8
Abstract: Fronto-temporal dementia (FTD) is a common type of presenile dementia, characterized by a heterogeneous clinical presentation that includes three main subtypes: behavioural-variant FTD, non-fluent/agrammatic variant primary progressive aphasia and semantic variant PPA. To better understand… read more here.
Keywords: fronto temporal; dementia; tensor imaging; ftd ... See more keywords
TREM2 variants in neurodegenerative disorders in the Polish population. Homozygosity and compound heterozygosity in FTD patients
Sign Up to like & getrecommendations! Published in 2018 at "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"
DOI: 10.1080/21678421.2018.1451894
Abstract: Abstract Activation of the TREM2 receptor on microglia stimulates phagocytosis and decreases the microglial proinflammatory response. Mutations in exon 2 of the TREM2 gene have been reported to be associated with various neurodegenerative diseases characterized… read more here.
Keywords: ftd; ftd patients; compound; polish population ... See more keywords
S54. THE RELATION OF FORMAL THOUGHT DISORDER WITH COGNITIVE FUNCTIONS, GLOBAL AND SOCIAL FUNCTIONING AND QUALITY OF LIFE IN PATIENTS WITH SCHIZOPHRENIA
Sign Up to like & getrecommendations! Published in 2020 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbaa031.120
Abstract: Abstract Background Formal thought disorder (FTD) is considered to be a core syndrome of schizophrenia (SZ). Although there are few studies investigating the cognitive correlates in FTD, etiopathogenesis of this cluster of symptoms is not… read more here.
Keywords: global social; disorder; ftd; quality life ... See more keywords
Dimensions of Formal Thought Disorder and Their Relation to Gray- and White Matter Brain Structure in Affective and Psychotic Disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Schizophrenia bulletin"
DOI: 10.1093/schbul/sbac002
Abstract: Factorial dimensions and neurobiological underpinnings of formal thought disorders (FTD) have been extensively investigated in schizophrenia spectrum disorders (SSD). However, FTD are also highly prevalent in other disorders. Still, there is a lack of knowledge… read more here.
Keywords: matter; gray white; white matter; ftd ... See more keywords
Frontotemporal degeneration genetic risk loci and transcription regulation as a possible mechanistic link to disease risk
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000031078
Abstract: The etiology of Frontotemporal Degeneration (FTD) is not well understood. Genetic studies have established common genetic variants (GVs) that are associated with increased FTD risk. We review previous genome wide association studies (GWAS) of FTD… read more here.
Keywords: risk loci; disease; etiology; ftd ... See more keywords
Experiences of families of people living with frontotemporal dementia: a qualitative systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Psychogeriatrics"
DOI: 10.1111/psyg.12837
Abstract: Frontotemporal dementia (FTD) is characterised by atrophy of the frontal and/or temporal lobes. People with FTD show language and emotional disturbances from onset, and communication problems usually affect people with FTD and their families even… read more here.
Keywords: families people; ftd; people living; experiences families ... See more keywords