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   Articles with "ftd" as a keyword



C9orf72 expansions are the most common cause of genetic frontotemporal dementia in a Southeast Asian cohort

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recommendations! Published in 2023 at "Annals of Clinical and Translational Neurology"

DOI: 10.1002/acn3.51744

Abstract: Frontotemporal dementia (FTD) encompasses a spectrum of neurodegenerative disorders, including behavioural variant FTD (bvFTD), semantic variant primary progressive aphasia (svPPA) and non‐fluent variant PPA (nfvPPA). While a strong genetic component is implicated in FTD, genetic… read more here.

Keywords: southeast asian; frontotemporal dementia; c9orf72 expansions; ftd ... See more keywords

Classifying Alzheimer's disease and frontotemporal dementia using machine learning with cross‐sectional and longitudinal magnetic resonance imaging data

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recommendations! Published in 2023 at "Human Brain Mapping"

DOI: 10.1002/hbm.26205

Abstract: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are common causes of dementia with partly overlapping, symptoms and brain signatures. There is a need to establish an accurate diagnosis and to obtain markers for disease tracking.… read more here.

Keywords: machine; alzheimer disease; ftd; cross sectional ... See more keywords

Improved chemoradiation treatment using trifluridine in human colorectal cancer cells in vitro.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.10.044

Abstract: We aimed to assess the combined effect of trifluridine (FTD) and ionizing radiation (IR) on colorectal cancer cells in vitro. Colorectal cancer cells, HT-29, HCT-15, and HCT 116, showing low, medium, and high sensitivity to… read more here.

Keywords: treatment; colorectal cancer; ftd; cancer cells ... See more keywords

The olfactory bulb proteotype differs across frontotemporal dementia spectrum.

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recommendations! Published in 2019 at "Journal of proteomics"

DOI: 10.1016/j.jprot.2019.04.011

Abstract: Mild olfactory dysfunction has been observed in frontotemporal dementias (FTD). However, the underlying molecular mechanisms associated to this deficit are poorly understood. We applied quantitative proteomics to analyze pathological effects on the olfactory bulb (OB)… read more here.

Keywords: ftd; ftld tdp43; olfactory bulb; protein kinase ... See more keywords

Driving and depression: Health professional's perspectives in Ireland

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recommendations! Published in 2017 at "Journal of transport and health"

DOI: 10.1016/j.jth.2017.09.003

Abstract: Abstract Background Assessing the fitness to drive (FTD) of individuals with depression is important for their safety and the safety of other road users. Although medical fitness to drive (FTD) guidelines exist in Ireland little… read more here.

Keywords: consultant psychiatrists; depression; general practitioners; ftd ... See more keywords

Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset

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recommendations! Published in 2024 at "Molecular Psychiatry"

DOI: 10.1038/s41380-024-02563-z

Abstract: Formal thought disorder (FTD) is a clinical key factor in schizophrenia, but the neurobiological underpinnings remain unclear. In particular, the relationship between FTD symptom dimensions and patterns of regional brain volume loss in schizophrenia remains… read more here.

Keywords: positive negative; formal thought; histology; thought disorder ... See more keywords

Shared and disease-specific pathways in frontotemporal dementia and Alzheimer’s and Parkinson’s diseases

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recommendations! Published in 2025 at "Nature Medicine"

DOI: 10.1038/s41591-025-03833-1

Abstract: Neurodegenerative diseases (NDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and frontotemporal dementia (FTD), exhibit distinct yet overlapping pathological mechanisms. Leveraging large-scale plasma proteomics data from the Global Neurodegeneration Proteomics Consortium, we analyzed 10,527… read more here.

Keywords: frontotemporal dementia; disease; specific pathways; ftd ... See more keywords
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Using diffusion tensor imaging to detect cortical changes in fronto-temporal dementia subtypes

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-68118-8

Abstract: Fronto-temporal dementia (FTD) is a common type of presenile dementia, characterized by a heterogeneous clinical presentation that includes three main subtypes: behavioural-variant FTD, non-fluent/agrammatic variant primary progressive aphasia and semantic variant PPA. To better understand… read more here.

Keywords: fronto temporal; dementia; tensor imaging; ftd ... See more keywords

Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD

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recommendations! Published in 2025 at "Communications Biology"

DOI: 10.1038/s42003-025-08368-2

Abstract: Genetic mutations in the progranulin gene, GRN, cause frontotemporal dementia and a lysosomal storage disorder. Using single-nuclei RNA sequencing of the post-mortem brain tissue from adult heterozygous pathogenic granulin variant (GRN+/−) carriers we find dysregulation… read more here.

Keywords: mertk axl; phagocytic receptors; ftd; grn ... See more keywords
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TREM2 variants in neurodegenerative disorders in the Polish population. Homozygosity and compound heterozygosity in FTD patients

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recommendations! Published in 2018 at "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"

DOI: 10.1080/21678421.2018.1451894

Abstract: Abstract Activation of the TREM2 receptor on microglia stimulates phagocytosis and decreases the microglial proinflammatory response. Mutations in exon 2 of the TREM2 gene have been reported to be associated with various neurodegenerative diseases characterized… read more here.

Keywords: ftd; ftd patients; compound; polish population ... See more keywords

S54. THE RELATION OF FORMAL THOUGHT DISORDER WITH COGNITIVE FUNCTIONS, GLOBAL AND SOCIAL FUNCTIONING AND QUALITY OF LIFE IN PATIENTS WITH SCHIZOPHRENIA

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recommendations! Published in 2020 at "Schizophrenia Bulletin"

DOI: 10.1093/schbul/sbaa031.120

Abstract: Abstract Background Formal thought disorder (FTD) is considered to be a core syndrome of schizophrenia (SZ). Although there are few studies investigating the cognitive correlates in FTD, etiopathogenesis of this cluster of symptoms is not… read more here.

Keywords: global social; disorder; ftd; quality life ... See more keywords