Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36
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DOI: 10.1016/j.neuron.2020.04.011
Abstract: GGGGCC hexanucleotide repeat expansions (HREs) in C9orf72 cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) and lead to the production of aggregating dipeptide repeat proteins (DPRs) via repeat associated non-AUG (RAN) translation. Here, we show… read more here.
Keywords: c9als ftd; dipeptide repeat; ftd sca36; pathology ... See more keywords