Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica"
DOI: 10.1007/s00401-019-01962-9
Abstract: Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) represents the most common pathological subtype of FTLD. We established the international FTLD-TDP whole-genome sequencing consortium to thoroughly characterize the known genetic… read more here.
Keywords: ftld; ftld tdp; whole genome; tdp patients ... See more keywords
Degeneration of the locus coeruleus is a common feature of tauopathies and distinct from TDP-43 proteinopathies in the frontotemporal lobar degeneration spectrum
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02210-1
Abstract: Neurodegeneration of the locus coeruleus (LC) in age-related neurodegenerative diseases such as Alzheimer’s disease (AD) is well documented. However, detailed studies of LC neurodegeneration in the full spectrum of frontotemporal lobar degeneration (FTLD) proteinopathies comparing… read more here.
Keywords: ftld; ftld tau; neurodegeneration; ftld tdp ... See more keywords
A longitudinal observation of brain structure between AD and FTLD
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2021.106604
Abstract: INTRODUCTION Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) are the leading causes of dementia. To better understand the disease development of cognitive function and anatomical structure in AD and FTLD, we analyzed the changes… read more here.
Keywords: ftld; lobe; structure ftld; brain ... See more keywords
Psychiatric symptoms of frontotemporal dementia and subcortical (co-)pathology burden: new insights
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac043
Abstract: Abstract Three subtypes of distinct pathological proteins accumulate throughout multiple brain regions and shape the heterogeneous clinical presentation of frontotemporal lobar degeneration (FTLD). Besides the main pathological subtypes, co-occurring pathologies are common in FTLD brain… read more here.
Keywords: tdp; psychiatric symptoms; brain; pathology ... See more keywords
Frontotemporal lobar degenerations: from basic science to clinical manifestations
Sign Up to like & getrecommendations! Published in 2019 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12537
Abstract: The relatively recently coined terms, frontotemporal dementia (FTD) and frontotemporal lobar degeneration (FTLD), are the result of over a century-long development of the concept of circumscribed cerebral atrophy, in which involvement of the frontal and… read more here.
Keywords: ftld; group; disease; frontotemporal lobar ... See more keywords
Clinical features of the behavioural variant of frontotemporal dementia that are useful for predicting underlying pathological subtypes of frontotemporal lobar degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Psychogeriatrics"
DOI: 10.1111/psyg.12334
Abstract: The behavioural variant of frontotemporal dementia (bvFTD) is the most common phenotype of frontotemporal lobar degeneration (FTLD). FTLD is divided into three main pathological subtypes: tau‐positive FTLD (FTLD‐tau), FTLD‐TAR DNA–binding protein (TDP), and FTLD‐Fused in… read more here.
Keywords: frontotemporal dementia; ftld; pathological subtypes; variant frontotemporal ... See more keywords
Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-022-00534-y
Abstract: Background Synapse degeneration is an early event in pathological frontotemporal lobar degeneration (FTLD). Consequently, a surrogate marker of synapse loss could be used to monitor early pathologic changes in patients with underlying FTLD. The aim… read more here.
Keywords: pathology; tau; ftld; degeneration ... See more keywords
Incidence of frontotemporal lobar degeneration in Italy
Sign Up to like & getrecommendations! Published in 2019 at "Neurology"
DOI: 10.1212/wnl.0000000000007498
Abstract: Objective The goal of the present work, based on a collaborative research registry in Italy (the Salento-Brescia Registry), was to assess the incidence of frontotemporal lobar degeneration (FTLD) and to define the frequencies of different… read more here.
Keywords: incidence; ftld; incidence frontotemporal; incidence rate ... See more keywords
Locus Coeruleus Degeneration Differs Between Frontotemporal Lobar Degeneration Subtypes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-220276
Abstract: Background: There are few studies on the locus coeruleus (LC) in frontotemporal lobar degeneration (FTLD) and the potential differences in the LC related to the underlying proteinopathy. Objective: The aim of this study was to… read more here.
Keywords: locus coeruleus; degeneration; frontotemporal lobar; ftld tau ... See more keywords
Early-stage differentiation between Alzheimer’s disease and frontotemporal lobe degeneration: Clinical, neuropsychology, and neuroimaging features
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.981451
Abstract: Background Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) are the two most common forms of neurodegenerative dementia. Although both of them have well-established diagnostic criteria, achieving early diagnosis remains challenging. Here, we aimed to… read more here.
Keywords: neuropsychology; disease; alzheimer disease; neuroimaging features ... See more keywords
Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.00682
Abstract: Digital pathology is increasingly prominent in neurodegenerative disease research, but variability in immunohistochemical staining intensity between staining batches prevents large-scale comparative studies. Here we provide a statistically rigorous method to account for staining batch effects… read more here.
Keywords: ftld; ftld tau; histopathology; pathology ... See more keywords