The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.
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DOI: 10.1016/j.celrep.2020.02.060
Abstract: Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and C9orf72-expansion carriers and might play a role in aging. To determine the physiological function… read more here.
Keywords: initial segment; axon initial; tmem106b; ftld risk ... See more keywords