Degeneration of the locus coeruleus is a common feature of tauopathies and distinct from TDP-43 proteinopathies in the frontotemporal lobar degeneration spectrum
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02210-1
Abstract: Neurodegeneration of the locus coeruleus (LC) in age-related neurodegenerative diseases such as Alzheimer’s disease (AD) is well documented. However, detailed studies of LC neurodegeneration in the full spectrum of frontotemporal lobar degeneration (FTLD) proteinopathies comparing… read more here.
Keywords: ftld; ftld tau; neurodegeneration; ftld tdp ... See more keywords
Signature laminar distributions of pathology in frontotemporal lobar degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Acta Neuropathologica"
DOI: 10.1007/s00401-021-02402-3
Abstract: Frontotemporal lobar degeneration (FTLD) with either tau (FTLD-tau) or TDP-43 (FTLD-TDP) inclusions are distinct proteinopathies that frequently cause similar frontotemporal dementia (FTD) clinical syndromes. FTD syndromes often display macroscopic signatures of neurodegeneration at the level… read more here.
Keywords: pathology; layer pathology; tdp; ftld tau ... See more keywords
A Practical Approach to Differentiate the Frontotemporal Tauopathy Subtypes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlaa100
Abstract: This study proposes a practical approach, using the minimum number of brain regions and stains, to consolidate previously published neuropathological criteria into one operationalized schema to differentiate subtypes of frontotemporal lobar degeneration with tau-immunopositive inclusions… read more here.
Keywords: approach; ftld tau; approach differentiate; practical approach ... See more keywords
Dysregulated Protein Phosphorylation in a Mouse Model of FTLD-Tau.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlac062
Abstract: The neocortex of P301S mice, used as a model of fronto-temporal lobar degeneration linked to tau mutation (FTLD-tau), and wild-type mice, both aged 9 months, were analyzed with conventional label-free phosphoproteomics and SWATH-MS (sequential window acquisition… read more here.
Keywords: protein phosphorylation; ftld tau; model; dysregulated protein ... See more keywords
Locus Coeruleus Degeneration Differs Between Frontotemporal Lobar Degeneration Subtypes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-220276
Abstract: Background: There are few studies on the locus coeruleus (LC) in frontotemporal lobar degeneration (FTLD) and the potential differences in the LC related to the underlying proteinopathy. Objective: The aim of this study was to… read more here.
Keywords: locus coeruleus; degeneration; frontotemporal lobar; ftld tau ... See more keywords
Sodium selenate as a therapeutic for tauopathies: A hypothesis paper
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.915460
Abstract: In a large proportion of individuals with fronto-temporal lobar degeneration (FTLD), the underlying pathology is associated with the misfolding and aggregation of the microtubule associated protein tau (FTLD-tau). With disease progression, widespread protein accumulation throughout… read more here.
Keywords: pathology; sodium selenate; tau; ftld tau ... See more keywords
Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.00682
Abstract: Digital pathology is increasingly prominent in neurodegenerative disease research, but variability in immunohistochemical staining intensity between staining batches prevents large-scale comparative studies. Here we provide a statistically rigorous method to account for staining batch effects… read more here.
Keywords: ftld; ftld tau; histopathology; pathology ... See more keywords