Orientation of FtsH protease homologs in Trypanosoma brucei inner mitochondrial membrane and its evolutionary implications.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2020.111282
Abstract: Trypanosoma brucei is an important human pathogen. In this study, we have focused on the characterization of FtsH protease, ATP-dependent membrane-bound mitochondrial enzyme important for regulation of protein abundance. We have determined localization and orientation… read more here.
Keywords: protease; ftsh; orientation; mitochondrial membrane ... See more keywords
Rewiring of the FtsH regulatory network by a single nucleotide change in saeS of Staphylococcus aureus
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DOI: 10.1038/s41598-017-08774-5
Abstract: In the Gram-positive pathogen Staphylococcus aureus, the membrane-bound ATP-dependent metalloprotease FtsH plays a critical role in resistance to various stressors. However, the molecular mechanism of the FtsH functions is not known. Here, we identified core… read more here.
Keywords: saes; staphylococcus aureus; regulatory network; ftsh ... See more keywords
A Membrane-Bound Transcription Factor is Proteolytically Regulated by the AAA+ Protease FtsH in Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bacteriology"
DOI: 10.1128/jb.00019-20
Abstract: Staphylococcus aureus is an important pathogenic bacterium causing various diseases in humans. In the bacterium, transcription is typically regulated by the transcription factors located in the cytoplasm. In this study, we report an atypical transcription… read more here.
Keywords: protease; membrane; transcription; transcription factor ... See more keywords
Recent Advances in Understanding the Structural and Functional Evolution of FtsH Proteases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.837528
Abstract: The FtsH family of proteases are membrane-anchored, ATP-dependent, zinc metalloproteases. They are universally present in prokaryotes and the mitochondria and chloroplasts of eukaryotic cells. Most bacteria bear a single ftsH gene that produces hexameric homocomplexes… read more here.
Keywords: advances understanding; understanding structural; recent advances; evolution ... See more keywords